Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 6/20 | 0.42 |
| ▸ | SPR | P35270 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27698609 | 0.90 | KMT2A (0.45) | KMT2AKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2186025 | 0.85 | KDM4E (0.46) | KMT2AKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2186733 | 0.80 | KDM4E (0.48) | KMT2AKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2188126 | 0.78 | ALDH1A1 (0.50) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2188470 | 0.77 | KDM4E (0.51) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2213735 | 0.76 | KDM4E (0.52) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL10719959 | 0.74 | KMT2A (0.49) | KMT2AKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2185602 | 0.74 | KDM4E (0.45) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL5774732 | 0.72 | KDM4E (0.43) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL5774731 | 0.71 | CCR2 (0.41) | KDM4EBRD4ALDH1A1POLBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031567-B | Novel heterocyclic NF-kB inhibitors | 4SC Corp.,Ltd. (DE) | 2011-12-21 | — | — | CN | claimed |
| CN-101031567-B | Novel heterocyclic NF-kB inhibitors | 4SC Corp.,Ltd. (DE) | 2011-12-21 | — | — | CN | disclosed |
| CN-101031567-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2007-09-05 | — | — | CN | disclosed |