Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30496448 | 1.00 | CYP11B1 (0.50) | CYP11B1CYP11B2SMN1; SMN2YTHDC1ALDH1A1 | |
| SCHEMBL29601245 | 0.91 | YTHDC1 (0.47) | CYP11B1CYP11B2SMN1; SMN2YTHDC1ALDH1A1 | |
| SCHEMBL183167 | 0.91 | YTHDC1 (0.47) | CYP11B1CYP11B2SMN1; SMN2YTHDC1ALDH1A1 | |
| SCHEMBL15921469 | 0.80 | P2RX7 (0.40) | ALDH1A1METHDAC6 | |
| SCHEMBL30020920 | 0.80 | MET (0.47) | CYP11B1CYP11B2SMN1; SMN2YTHDC1ALDH1A1 | |
| SCHEMBL6900306 | 0.80 | MET (0.47) | CYP11B1CYP11B2SMN1; SMN2YTHDC1ALDH1A1 | |
| SCHEMBL29601391 | 0.77 | MEN1 (0.46) | KMT2A | |
| SCHEMBL21883489 | 0.76 | SMN1; SMN2 (0.56) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7009400 | 0.76 | HDAC6 (0.41) | CYP11B1CYP11B2SMN1; SMN2YTHDC1MAPK1 | |
| SCHEMBL3425599 | 0.76 | ADORA2A (0.39) | CYP11B1CYP11B2SMN1; SMN2YTHDC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210214357-A1 | HYPOXANTHINE COMPOUNDS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-07-15 | — | — | US | disclosed |
| US-20210214357-A1 | HYPOXANTHINE COMPOUNDS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-07-15 | — | — | US | disclosed |
| EP-3819299-A1 | HYPOXANTHINE COMPOUND | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-05-12 | — | — | EP | disclosed |
| CN-112673008-A | Hypoxanthine compound | 橘生药品工业株式会社 | 2021-04-16 | — | — | CN | disclosed |
| WO-2020054825-A1 | HYPOXANTHINE COMPOUND | キッセイ薬品工業株式会社 | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210214357-A1 | HYPOXANTHINE COMPOUNDS | HPRT1, DHPS, PAH | CYP11B1 842/4885CYP11B2 989/4885SMN1; SMN2 3418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.