Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186625 | 0.89 | MAPT (0.56) | NPSR1L3MBTL1ALDH1A1LMNAKMT2A | |
| SCHEMBL2187333 | 0.84 | MAPT (0.51) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKMT2A | |
| SCHEMBL2187555 | 0.83 | MEN1 (0.50) | KDM4ESMN1; SMN2NPSR1LMNAKMT2A | |
| SCHEMBL2186974 | 0.83 | CACNA2D1 (0.48) | KDM4ESMN1; SMN2NPSR1ALDH1A1LMNA | |
| SCHEMBL2187029 | 0.81 | L3MBTL1 (0.46) | SMN1; SMN2HSD17B10HPGDNPSR1L3MBTL1 | |
| SCHEMBL2187130 | 0.81 | KMT2A (0.56) | SMN1; SMN2HSD17B10NPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL2188442 | 0.81 | NPC1 (0.47) | SMN1; SMN2HPGDL3MBTL1ALDH1A1LMNA | |
| SCHEMBL27679675 | 0.80 | LMNA (0.50) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKMT2A | |
| SCHEMBL2187707 | 0.80 | MLNR (0.41) | SMN1; SMN2L3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL2186441 | 0.78 | L3MBTL1 (0.58) | HSD17B10L3MBTL1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |