Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186581 | 0.90 | KMT2A (0.52) | KMT2ASMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL2188486 | 0.84 | MAPK1 (0.40) | KMT2ASMN1; SMN2ALDH1A1LMNAALOX15 | |
| SCHEMBL2188442 | 0.79 | NPC1 (0.47) | KMT2ASMN1; SMN2ALDH1A1LMNAALOX15 | |
| SCHEMBL2185718 | 0.78 | LMNA (0.40) | ALDH1A1LMNAALOX15TSHRMAPK1 | |
| SCHEMBL27679675 | 0.77 | LMNA (0.50) | KMT2ASMN1; SMN2ALDH1A1LMNAALOX15 | |
| SCHEMBL2186946 | 0.77 | LMNA (0.46) | SMN1; SMN2ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL2187044 | 0.77 | TRPC6 (0.40) | KMT2ASMN1; SMN2ALDH1A1LMNAMAPK1 | |
| SCHEMBL2186813 | 0.76 | SCD5 (0.43) | SMN1; SMN2ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL2187314 | 0.74 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL2187707 | 0.73 | MLNR (0.41) | SMN1; SMN2ALDH1A1LMNAALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |