Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.40 |
| ▸ | PPOX | P50336 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25360261 | 0.78 | PDK2 (0.37) | AKR1B1AKR1A1PPOXHTR2CHTR2A | |
| SCHEMBL11819586 | 0.77 | AKR1B1 (0.40) | PGRAKR1B1AKR1A1PPOXF7 | |
| SCHEMBL394558 | 0.77 | HRH3 (0.41) | HTR2CHTR2AHTR2BDRD2 | |
| Hydrochloric Acid SCHEMBL2101720 | 0.76 | HRH3 (0.41) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL22493790 | 0.75 | HTR2C (0.42) | PPOXHTR2CHTR2AHTR2BF7 | |
| SCHEMBL21856169 | 0.75 | F7 (0.44) | PPOXHTR2CHTR2AHTR2BF7 | |
| SCHEMBL29506005 | 0.75 | F7 (0.44) | PPOXHTR2CHTR2AHTR2BF7 | |
| Hydrochloric Acid SCHEMBL21855899 | 0.74 | HTR2C (0.41) | PPOXHTR2CHTR2AHTR2BF7 | |
| SCHEMBL26174678 | 0.73 | JAK2 (0.48) | — | |
| SCHEMBL13001434 | 0.73 | ALDH1A1 (0.40) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250195483-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMA (US) | 2025-06-19 | — | — | US | disclosed |
| EP-4476207-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | SYNGENTA CROP PROTECTION LLC | 2014-01-30 | — | — | US | disclosed |
| US-8354423-B2 | Insecticidal spironindane derivatives | SYNGENTA CROP PROTECTION LLC (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1697327-B1 | INSECTICIDAL SPIROINDANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1697327-A1 | INSECTICIDAL SPIROINDANE DERIVATIVES | Syngenta Participations AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058836-A1 | INSECTICIDAL SPIROINDANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250195483-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, PNLIP, SAAL1 | PGR 4384/4885AKR1B1 773/4885AKR1A1 927/4885 |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | NR1D1, NR1D2, NR1I3 | PGR 1289/4885AKR1B1 67/4885AKR1A1 36/4885 |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | NR1D1, NR1D2, NR1I3 | PGR 1289/4885AKR1B1 67/4885AKR1A1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.