Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PTPRA | P18433 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | AGER | Q15109 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16058321 | 1.00 | ADAMTS5 (0.52) | ADAMTS5KMT2AMEN1PTPRAGAA | |
| Bromide SCHEMBL29831731 | 0.99 | ADAMTS5 (0.51) | ADAMTS5KMT2AMEN1PTPRAGAA | |
| SCHEMBL5573300 | 0.82 | ADAMTS5 (0.73) | ADAMTS5KMT2AGAAPOLBMAPT | |
| SCHEMBL5573297 | 0.82 | ADAMTS5 (0.73) | ADAMTS5KMT2AGAAPOLBMAPT | |
| SCHEMBL28583121 | 0.80 | MEN1 (0.48) | ADAMTS5KMT2AMEN1PTPRAGAA | |
| SCHEMBL5572738 | 0.77 | GAA (0.59) | KMT2AMEN1GAAALDH1A1CYP3A4 | |
| SCHEMBL17481680 | 0.76 | AGER (0.54) | ADAMTS5KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5573156 | 0.76 | AGER (0.54) | ADAMTS5KMT2AALDH1A1MAPTKEAP1 | |
| SCHEMBL21885546 | 0.75 | TDP1 (0.58) | ADAMTS5KMT2AALDH1A1POLBMAPT | |
| SCHEMBL16058523 | 0.75 | TDP1 (0.58) | ADAMTS5KMT2AALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10639308-B2 | sGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2020-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10639308-B2 | sGC stimulators | PTGIS, CGAS, GUCY1A1 | ADAMTS5 4259/4885KMT2A 4250/4885MEN1 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.