Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 11/20 | 0.40 |
| ▸ | KCNK10 | P57789 | 9/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27783028 | 0.75 | KCNK2 (0.43) | KCNK2KCNK10KIF11ALDH1A1LMNA | |
| SCHEMBL21885673 | 0.73 | ALDH1A1 (0.58) | KCNK2KCNK10ALDH1A1KDM4EHTT | |
| SCHEMBL21885669 | 0.72 | KCNK2 (0.39) | KCNK2KCNK10KIF11ALDH1A1KDM4E | |
| SCHEMBL29643314 | 0.72 | KCNK2 (0.39) | KCNK2KCNK10KIF11ALDH1A1KDM4E | |
| SCHEMBL21885651 | 0.70 | WDR5 (0.34) | KIF11CA1CA2L3MBTL1 | |
| SCHEMBL6090788 | 0.70 | KDM4E (0.52) | KCNK2KCNK10KIF11ALDH1A1KDM4E | |
| SCHEMBL21885668 | 0.68 | TAS2R14 (0.48) | KIF11ALDH1A1LMNAHTTMAPT | |
| SCHEMBL21885653 | 0.68 | KIF11 (0.48) | KCNK2KCNK10KIF11ALDH1A1KDM4E | |
| SCHEMBL15068206 | 0.68 | KCNK2 (0.43) | KCNK2KCNK10KIF11ALDH1A1KDM4E | |
| SCHEMBL24616823 | 0.66 | KDM4E (0.52) | KCNK2KCNK10KIF11ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601235-B1 | BICYCLIC HETEROARYL DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF | XWPHARMA LTD (KY) | 2026-03-04 | — | — | EP | disclosed |
| US-11639337-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XWPharma Ltd. (KY) | 2023-05-02 | — | — | US | disclosed |
| US-20220298127-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2022-09-22 | — | — | US | disclosed |
| CN-115025086-A | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2022-09-09 | — | — | CN | disclosed |
| US-11401249-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XWPharma Ltd. (KY) | 2022-08-02 | — | — | US | disclosed |
| CN-110709386-B | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2022-06-07 | — | — | CN | disclosed |
| US-20210094925-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2021-04-01 | — | — | US | disclosed |
| US-10882832-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XW LABORATORIES INC. (KY) | 2021-01-05 | — | — | US | disclosed |
| US-20200181102-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2020-06-11 | — | — | US | disclosed |
| US-10640476-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XW LABORATORIES INC. (KY) | 2020-05-05 | — | — | US | disclosed |
| CN-110709386-A | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2020-01-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298127-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | KCNK2 1025/4885KCNK10 1741/4885KIF11 3389/4885 |
| US-10882832-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | KCNK2 1025/4885KCNK10 1741/4885KIF11 3389/4885 |
| US-11401249-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | KCNK2 1025/4885KCNK10 1741/4885KIF11 3389/4885 |
| US-20200181102-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | KCNK2 1025/4885KCNK10 1741/4885KIF11 3389/4885 |
| US-10640476-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | KCNK2 1025/4885KCNK10 1741/4885KIF11 3389/4885 |
| US-11639337-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | KCNK2 1025/4885KCNK10 1741/4885KIF11 3389/4885 |
| US-20210094925-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | KCNK2 1025/4885KCNK10 1741/4885KIF11 3389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.