Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15563193 | 0.79 | GAA (0.54) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL9475099 | 0.79 | POLB (0.65) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL5660190 | 0.75 | THRB (0.61) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL2539977 | 0.73 | ALDH1A1 (0.58) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL4610185 | 0.73 | PDK1 (0.60) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL21885655 | 0.73 | KCNK2 (0.40) | ALDH1A1MAPTTSHRHTTKDM4E | |
| SCHEMBL21885662 | 0.72 | GAA (0.57) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL29643277 | 0.72 | GAA (0.57) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL4199019 | 0.71 | ALDH1A1 (0.55) | ALDH1A1GAAPOLBTHRBKDR | |
| SCHEMBL21885651 | 0.70 | WDR5 (0.34) | WDR5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601235-B1 | BICYCLIC HETEROARYL DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF | XWPHARMA LTD (KY) | 2026-03-04 | — | — | EP | disclosed |
| US-11639337-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XWPharma Ltd. (KY) | 2023-05-02 | — | — | US | disclosed |
| US-20220298127-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2022-09-22 | — | — | US | disclosed |
| CN-115025086-A | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2022-09-09 | — | — | CN | disclosed |
| US-11401249-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XWPharma Ltd. (KY) | 2022-08-02 | — | — | US | disclosed |
| CN-110709386-B | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2022-06-07 | — | — | CN | disclosed |
| US-20210094925-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2021-04-01 | — | — | US | disclosed |
| US-10882832-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XW LABORATORIES INC. (KY) | 2021-01-05 | — | — | US | disclosed |
| US-20200181102-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | XWPharma Ltd. (KY) | 2020-06-11 | — | — | US | disclosed |
| US-10640476-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | XW LABORATORIES INC. (KY) | 2020-05-05 | — | — | US | disclosed |
| CN-110709386-A | Bicyclic heteroaryl derivatives, their preparation and use | 凯瑞康宁生物工程（武汉）有限公司 | 2020-01-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298127-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 742/4885GAA 1177/4885POLB 3699/4885 |
| US-10882832-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 742/4885GAA 1177/4885POLB 3699/4885 |
| US-11401249-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 742/4885GAA 1177/4885POLB 3699/4885 |
| US-20200181102-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 742/4885GAA 1177/4885POLB 3699/4885 |
| US-10640476-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 742/4885GAA 1177/4885POLB 3699/4885 |
| US-11639337-B2 | Bicyclic heteroaryl derivatives and preparation and uses thereof | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 742/4885GAA 1177/4885POLB 3699/4885 |
| US-20210094925-A1 | BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF | GRIN2A, GRIN2C, GRIN3A | ALDH1A1 742/4885GAA 1177/4885POLB 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.