SCHEMBL2188576

SCHEMBL2188576

O=C(c1ccc(F)cc1)C1(O)C=CC(c2ccccc2)=CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.39
MEN1 O00255 5/20 0.39
POLB P06746 3/20 0.39
SLC6A7 Q99884 1/20 0.36
BCL2L1 Q07817 1/20 0.36
BAD Q92934 1/20 0.36
HSD11B1 P28845 2/20 0.34
KDM4E B2RXH2 3/20 0.33
NPC1 O15118 3/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
RAB9A P51151 3/20 0.33
MAPT P10636 2/20 0.33
ALDH1A1 P00352 1/20 0.33
PPARG P37231 1/20 0.33
NCOA2 Q15596 1/20 0.33
NCOA1 Q15788 1/20 0.33
NCOA3 Q9Y6Q9 1/20 0.33
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
GRIN2B Q13224 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1119645 0.79 THRB (0.35) TDP1
SCHEMBL9814885 0.76 LMNA (0.35) KMT2AMEN1POLBSLC6A7BCL2L1
SCHEMBL8970782 0.73 MEN1 (0.38) KMT2AMEN1KDM4ENPC1SMN1; SMN2
SCHEMBL4043808 0.72 LMNA (0.36) KMT2AMEN1POLBKDM4ESMN1; SMN2
SCHEMBL5320073 0.71 LMNA (0.36) KMT2AMEN1NPC1SMN1; SMN2RAB9A
SCHEMBL28240002 0.71 LMNA (0.33) NPC1RAB9AALDH1A1CES2CES1
SCHEMBL10533333 0.71 CES2 (0.40) KMT2AMEN1NPC1RAB9AMAPT
SCHEMBL28621116 0.71
SCHEMBL28383051 0.71 CHRNA1 (0.30)
Hydrogen Sulfide SCHEMBL27540779 0.70 LMNA (0.36) KMT2AMEN1NPC1SMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101466770-B Polymeric materials VICTREX MFG LTD 2012-11-14 CN disclosed
CN-101466771-B Polymeric materials VICTREX MFG LTD 2012-07-25 CN disclosed
EP-2342261-A1 IMPROVED METHOD FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S AND IMPROVED METHOD FOR PROVIDING A SODIUM CARBONATE SUITABLE FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S Solvay Advanced Polymers, L.L.C. (US) 2011-07-13 EP disclosed
WO-2010046487-A1 IMPROVED METHOD FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S AND IMPROVED METHOD FOR PROVIDING A SODIUM CARBONATE SUITABLE FOR THE MANUFACTURE OF POLY(ARYL ETHER KETONE)S SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2010-04-29 WO disclosed
CN-101466771-A Polymeric materials VICTREX MFG LTD (GB) 2009-06-24 CN disclosed
CN-101466770-A Polymeric materials VICTREX MFG LTD (GB) 2009-06-24 CN disclosed