Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.59 |
| ▸ | HTR3B | O95264 | 1/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12463006 | 1.00 | L3MBTL1 (0.60) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL6887388 | 0.87 | HTR3E (0.63) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL6886979 | 0.87 | SIGMAR1 (0.62) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL2190458 | 0.87 | SIGMAR1 (0.62) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL6886806 | 0.87 | SIGMAR1 (0.65) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL6889532 | 0.84 | CXCR6 (0.57) | SIGMAR1HTR3EHTR3BCHRM4CHRM5 | |
| SCHEMBL6886856 | 0.81 | SIGMAR1 (0.53) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL6887464 | 0.81 | SIGMAR1 (0.57) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL6885993 | 0.80 | SIGMAR1 (0.59) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 | |
| SCHEMBL6885989 | 0.80 | SIGMAR1 (0.72) | L3MBTL1SIGMAR1HTR3EHTR3BCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523562-B1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | ASTRAEA THERAPEUTICS LLC (US) | 2019-01-02 | — | — | EP | disclosed |
| US-20180318270-A1 | Selective High Affinity Alpha3Beta4 Nicotinic Acetycholine Receptor Antagonists | ASTRAEA THERAPEUTICS LLC (US) | 2018-11-08 | — | — | US | disclosed |
| US-10085975-B2 | Selective high affinity α3β4 nicotinic acetylcholine receptor antagonists | Astraea Therapeutics, Inc. (US) | 2018-10-02 | — | — | US | disclosed |
| US-20170224665-A1 | SELECTIVE HIGH AFFINITY ALFA3BETA4 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | Astraea Therapeutics (US) | 2017-08-10 | — | — | US | disclosed |
| US-20170224665-A1 | SELECTIVE HIGH AFFINITY ALFA3BETA4 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | Astraea Therapeutics (US) | 2017-08-10 | — | — | US | disclosed |
| US-9670198-B2 | Nicotinic acetylcholine receptor modulators | ASTRAEA THERAPEUTICS, LLC (US) | 2017-06-06 | — | — | US | disclosed |
| US-9670198-B2 | Nicotinic acetylcholine receptor modulators | ASTRAEA THERAPEUTICS, LLC (US) | 2017-06-06 | — | — | US | disclosed |
| US-9062042-B2 | Nicotinic acetylcholine receptor modulators | ASTRAEA THERAPEUTICS, LLC (US) | 2015-06-23 | — | — | US | disclosed |
| US-9062042-B2 | Nicotinic acetylcholine receptor modulators | ASTRAEA THERAPEUTICS, LLC (US) | 2015-06-23 | — | — | US | disclosed |
| US-20150148541-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Astraea Therapeutics (US) | 2015-05-28 | — | — | US | disclosed |
| US-20150148541-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Astraea Therapeutics (US) | 2015-05-28 | — | — | US | disclosed |
| US-20110172264-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | ASTRAEA THERAPEUTICS, LLC | 2011-07-14 | — | — | US | disclosed |
| US-20110172264-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | ASTRAEA THERAPEUTICS, LLC | 2011-07-14 | — | — | US | disclosed |
| WO-2011085389-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | ASTRAEA THERAPEUTICS, LLC (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172264-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA4, CHRNA3, CHRNA6 | L3MBTL1 1609/4885SIGMAR1 76/4885HTR3E 139/4885 |
| US-20180318270-A1 | Selective High Affinity Alpha3Beta4 Nicotinic Acetycholine Receptor Antagonists | CHRNA3, CHRNA4, CHRNA2 | L3MBTL1 2688/4885SIGMAR1 38/4885HTR3E 124/4885 |
| US-20170224665-A1 | SELECTIVE HIGH AFFINITY ALFA3BETA4 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | CHRNA3, CHRNA4, CHRNB3 | L3MBTL1 1813/4885SIGMAR1 35/4885HTR3E 181/4885 |
| US-10085975-B2 | Selective high affinity α3β4 nicotinic acetylcholine receptor antagonists | CHRNA3, CHRNA4, CHRNA2 | L3MBTL1 2144/4885SIGMAR1 58/4885HTR3E 141/4885 |
| US-20150148541-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA4, CHRNA2 | L3MBTL1 2940/4885SIGMAR1 60/4885HTR3E 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.