Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.54 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2195452 | 0.79 | NFE2L2 (0.46) | NFE2L2IDO1MCHR1HPGDCTSS | |
| SCHEMBL1625928 | 0.78 | HSD11B1 (0.44) | HSD11B1HSD11B2CTSSCTSLCTSK | |
| SCHEMBL29705644 | 0.78 | NFE2L2 (0.39) | HSD11B1HSD11B2NFE2L2IDO1MCHR1 | |
| SCHEMBL18721894 | 0.77 | HSD11B1 (0.42) | HSD11B1HSD11B2NFE2L2CHRM4CTSS | |
| SCHEMBL2585221 | 0.76 | DPP4 (0.52) | HSD11B1HSD11B2ALOX5APFEN1DPP4 | |
| SCHEMBL31753279 | 0.76 | GPR119 (0.51) | — | |
| SCHEMBL2195636 | 0.75 | HPGD (0.47) | NFE2L2IDO1MCHR1HPGD | |
| SCHEMBL23163700 | 0.75 | NFE2L2 (0.39) | HSD11B1HSD11B2NFE2L2IDO1MCHR1 | |
| SCHEMBL2695269 | 0.74 | DPP4 (0.53) | HSD11B1HSD11B2ALOX5APFEN1DPP4 | |
| SCHEMBL23163619 | 0.74 | NFE2L2 (0.36) | HSD11B1HSD11B2NFE2L2IDO1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172230-A1 | UREA COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2011-07-14 | — | — | US | disclosed |
| EP-2065369-A1 | UREA COMPOUND OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2009-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172230-A1 | UREA COMPOUND OR SALT THEREOF | FAAH, FAAH2, UTS2R | HSD11B1 1376/4885HSD11B2 1452/4885NFE2L2 1770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.