Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 7/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255580 | 0.93 | HTR1A (0.54) | HTR1ADRD3DRD2DRD1PARP1 | |
| SCHEMBL1255429 | 0.93 | DRD3 (0.52) | HTR1ADRD3DRD2DRD1PARP1 | |
| SCHEMBL5214854 | 0.91 | DRD3 (0.50) | HTR1ADRD3DRD2DRD1PARP1 | |
| SCHEMBL2198353 | 0.87 | LMNA (0.42) | HTR1ADRD3DRD2DRD1PARP1 | |
| SCHEMBL2196560 | 0.81 | LMNA (0.41) | HTR1ADRD3DRD2DRD1PARP1 | |
| SCHEMBL2224598 | 0.81 | HTR1A (0.43) | HTR1ADRD3DRD2DRD1PARP1 | |
| SCHEMBL2194155 | 0.79 | DRD2 (0.49) | HTR1ADRD3DRD2ALDH1A1CYP2D6 | |
| SCHEMBL2194422 | 0.79 | HTR1A (0.47) | HTR1ADRD3DRD2DRD1DRD4 | |
| SCHEMBL2195771 | 0.79 | ADRA1D (0.42) | HTR1ADRD2DRD4ADRA1DHTR2A | |
| SCHEMBL2196865 | 0.79 | HTR1A (0.47) | HTR1ADRD3DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051219-A1 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | HELTON DAVID REED (US) | 2015-02-19 | — | — | US | claimed |
| US-20110172242-A1 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | ABRAXIS BIOSCIENCE, INC. | 2011-07-14 | — | — | US | claimed |
| US-20090264443-A1 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | ABRAXIS BIOSCIENCE, INC. | 2009-10-22 | — | — | US | claimed |
| US-20050107439-A1 | Composition and method for treating emesis | HELTON DAVID R (US) | 2005-05-19 | — | — | US | claimed |
| US-20050107439-A1 | Composition and method for treating emesis | HELTON DAVID R (US) | 2005-05-19 | — | — | US | disclosed |
| US-20050107439-A1 | Composition and method for treating emesis | HELTON DAVID R (US) | 2005-05-19 | — | — | US | disclosed |
| US-20050107439-A1 | Composition and method for treating emesis | HELTON DAVID R (US) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172242-A1 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | DDT, CYP4X1, AHR | HTR1A 440/4885DRD3 1448/4885DRD2 1585/4885 |
| US-20150051219-A1 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | DDT, CYP4X1, AHR | HTR1A 440/4885DRD3 1448/4885DRD2 1585/4885 |
| US-20050107439-A1 | Composition and method for treating emesis | VIP, HNMT, FABP2 | HTR1A 254/4885DRD3 3181/4885DRD2 2071/4885 |
| US-20090264443-A1 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | DDT, CYP4X1, AHR | HTR1A 440/4885DRD3 1448/4885DRD2 1585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.