Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255429 | 0.98 | DRD3 (0.52) | DRD3HTR1ADRD2TMEM97SIGMAR1 | |
| SCHEMBL1255580 | 0.96 | HTR1A (0.54) | DRD3HTR1ADRD2SIGMAR1DRD1 | |
| SCHEMBL2193115 | 0.91 | HTR1A (0.47) | DRD3HTR1ADRD2SIGMAR1DRD1 | |
| SCHEMBL2196560 | 0.86 | LMNA (0.41) | DRD3HTR1ADRD2SIGMAR1DRD1 | |
| SCHEMBL2224598 | 0.84 | HTR1A (0.43) | DRD3HTR1ADRD2SIGMAR1DRD1 | |
| SCHEMBL2198353 | 0.79 | LMNA (0.42) | DRD3HTR1ADRD2DRD1PARP1 | |
| SCHEMBL2195924 | 0.78 | SIGMAR1 (0.57) | DRD3HTR1ADRD2SIGMAR1ADRA1D | |
| SCHEMBL2192247 | 0.78 | ALDH1A1 (0.46) | DRD3HTR1ADRD2DRD4ALDH1A1 | |
| SCHEMBL2197706 | 0.78 | KDM4E (0.48) | DRD3HTR1ADRD2TMEM97SIGMAR1 | |
| SCHEMBL2194931 | 0.78 | KDM4E (0.47) | DRD3HTR1ADRD2TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412028-B1 | TETRAHYDROINDOLONE DERIVATIVES LINKED TO ARYLPIPERAZINES | SPECTRUM PHARMACEUTICALS INC (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1412028-B1 | TETRAHYDROINDOLONE DERIVATIVES LINKED TO ARYLPIPERAZINES | SPECTRUM PHARMACEUTICALS INC (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1764134-A2 | Tetrahydroindolone and purine derivatives linked to arylpiperazines | Spectrum Pharmaceuticals, Inc. (US) | 2007-03-21 | — | — | EP | disclosed |
| EP-1764134-A2 | Tetrahydroindolone and purine derivatives linked to arylpiperazines | Spectrum Pharmaceuticals, Inc. (US) | 2007-03-21 | — | — | EP | disclosed |
| US-6770638-B2 | PSYCHOLOGICAL DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS | SPECTRUM PHARMACEUTICALS, INC. | 2004-08-03 | — | — | US | disclosed |
| EP-1412028-A1 | TETRAHYDROINDOLONE AND PURINE DERIVATIVES LINKED TO ARYLPIPERAZINES | Neotherapeutics, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| US-20030114463-A1 | Tetrahydroindolone and purine derivatives linked to arylpiperazines | SPECTRUM PHARMACEUTICALS, INC. | 2003-06-19 | — | — | US | disclosed |
| WO-2003011396-A1 | TETRAHYDROINDOLONE AND PURINE DERIVATIVES LINKED TO ARYLPIPERAZINES | NEOTHERAPEUTICS, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
| WO-2003011396-A1 | TETRAHYDROINDOLONE AND PURINE DERIVATIVES LINKED TO ARYLPIPERAZINES | NEOTHERAPEUTICS, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114463-A1 | Tetrahydroindolone and purine derivatives linked to arylpiperazines | HTR5A, GABRA5, HTR2C | DRD3 65/4885HTR1A 12/4885DRD2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.