Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19684092 | 0.93 | MEN1 (0.34) | MEN1KMT2ASMN1; SMN2RAB9APSEN1 | |
| SCHEMBL19684096 | 0.91 | MEN1 (0.33) | MEN1KMT2ASMN1; SMN2RAB9APSEN1 | |
| SCHEMBL23889705 | 0.86 | RAB9A (0.34) | MEN1KMT2ASMN1; SMN2RAB9APSEN1 | |
| SCHEMBL19684093 | 0.84 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2ALDH1A1HDAC3 | |
| SCHEMBL19698830 | 0.84 | ALDH1A1 (0.33) | MEN1KMT2ASMN1; SMN2RAB9APSEN1 | |
| SCHEMBL23889723 | 0.83 | PSEN1 (0.34) | MEN1KMT2ASMN1; SMN2RAB9APSEN1 | |
| SCHEMBL22220123 | 0.77 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1HDAC3 | |
| SCHEMBL19774664 | 0.76 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL19683917 | 0.75 | SMN1; SMN2 (0.36) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL20830999 | 0.73 | OPRM1 (0.36) | KMT2ASMN1; SMN2RAB9APSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | GENENTECH, INC. (US) | 2020-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | SHBG, EPCAM, ITGAV | MEN1 3118/4885KMT2A 503/4885SMN1; SMN2 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.