Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | FPR3 | P25089 | 2/20 | 0.31 |
| ▸ | FPR2 | P25090 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19684092 | 0.93 | MEN1 (0.34) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23889723 | 0.90 | PSEN1 (0.34) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19698830 | 0.90 | ALDH1A1 (0.33) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21949515 | 0.86 | MEN1 (0.34) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19684096 | 0.83 | MEN1 (0.33) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20830999 | 0.81 | OPRM1 (0.36) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22220123 | 0.77 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL19698802 | 0.77 | KMT2A (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL25091347 | 0.75 | PSEN1 (0.36) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22219876 | 0.75 | HTR1A (0.36) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464280-B1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2021-10-06 | — | — | EP | disclosed |