Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 3/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | APOB | P04114 | 1/20 | 0.35 |
| ▸ | MTTP | P55157 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196468 | 0.85 | MCHR1 (0.39) | MCHR1DGAT1SCN1ASCN5ASCN9A | |
| SCHEMBL2196467 | 0.85 | MCHR1 (0.39) | MCHR1DGAT1SCN1ASCN5ASCN9A | |
| SCHEMBL2280669 | 0.84 | DGAT1 (0.37) | MCHR1DGAT1OPRD1TDP2TRPV1 | |
| SCHEMBL2279505 | 0.83 | SCN1A (0.39) | MCHR1SCN1ASCN5ASCN9ABRD4 | |
| SCHEMBL13719274 | 0.81 | CRBN (0.42) | HTR2AHTR2CHTR2BTDP2 | |
| SCHEMBL2197280 | 0.80 | DGAT1 (0.41) | MCHR1DGAT1SCN1ASCN5ASCN9A | |
| SCHEMBL2198200 | 0.78 | MCHR1 (0.36) | MCHR1SCN1ASCN5ASCN9ABRD4 | |
| SCHEMBL2198162 | 0.78 | TDP2 (0.42) | DGAT1TDP2BRD4CREBBPAPOB | |
| SCHEMBL2280666 | 0.77 | DGAT1 (0.39) | MCHR1DGAT1OPRD1TDP2BRD4 | |
| SCHEMBL2179791 | 0.76 | JAK2 (0.44) | MCHR1DGAT1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |