Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ATF1 | P18846 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL975710 | 0.83 | MAPT (0.60) | MAPTALDH1A1POLBHSD11B1GAA | |
| SCHEMBL14269337 | 0.83 | MAPT (0.56) | MAPTALDH1A1POLBHSD11B1GAA | |
| SCHEMBL5206178 | 0.81 | MAPT (0.55) | MAPTALDH1A1POLBHSD11B1GAA | |
| SCHEMBL16217224 | 0.80 | MAPT (0.54) | MAPTALDH1A1POLBHSD11B1GAA | |
| SCHEMBL6137447 | 0.79 | MAPT (0.37) | MAPTALDH1A1POLBHSD11B1MEN1 | |
| SCHEMBL883065 | 0.79 | MAPT (0.37) | MAPTALDH1A1POLBHSD11B1MEN1 | |
| SCHEMBL2310145 | 0.79 | MEN1 (0.49) | MAPTALDH1A1POLBHSD11B1MEN1 | |
| SCHEMBL13544346 | 0.79 | MAPT (0.52) | MAPTALDH1A1POLBHSD11B1GAA | |
| SCHEMBL12883301 | 0.79 | MAPT (0.52) | MAPTALDH1A1POLBHSD11B1GAA | |
| SCHEMBL7988803 | 0.79 | MAPT (0.52) | MAPTALDH1A1POLBHSD11B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380767-A | Thiazole amide compound containing diphenylamino group and preparation method and application thereof | 安徽理工大学 | 2022-04-22 | — | — | CN | claimed |
| CN-107540628-A | A kind of amidation process process of thiazole carboxamides production technology | 宁夏海诚电化信息科技有限公司 | 2018-01-05 | — | — | CN | claimed |
| WO-2025149628-A1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF NICOTINAMIDE N-METHYL TRANSFERASE | ASTRAZENECA AB (SE) | 2025-07-17 | — | — | WO | disclosed |
| CN-119591560-B | Synthesis method of thifluzamide | 湖南速博生物技术有限公司 | 2025-04-29 | — | — | CN | disclosed |
| CN-119751376-A | Preparation method of thifluzamide | 广东禾康精细化工有限公司 | 2025-04-04 | — | — | CN | disclosed |
| US-12264147-B2 | Substituted carboxamides as inhibitors of WDR5 protein-protein binding | Propellon Therapeutics Inc. (CA) | 2025-04-01 | — | — | US | disclosed |
| CN-119591560-A | Synthesis method of thifluzamide | 湖南速博生物技术有限公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-116063285-B | Substituted pyrimidine (thio) ester compound and application thereof | 沈阳中化农药化工研发有限公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-114560826-B | Thiazole amide compound containing diphenyl ether group and preparation method and application thereof | 安徽理工大学 | 2024-06-25 | — | — | CN | disclosed |
| CN-117551037-A | Compounds as succinate dehydrogenase inhibitors and uses thereof | 华东理工大学 | 2024-02-13 | — | — | CN | disclosed |
| US-20230219926-A1 | SUBSTITUTED CARBOXAMIDES AS INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | FACIT INC. (CA) | 2023-07-13 | — | — | US | disclosed |
| EP-0315502-B1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND AGRICULTURAL OR HORTICULTURAL FUNGICIDES CONTAINING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-06-02 | — | — | EP | disclosed |
| EP-0276177-B1 | HETEROCYCLIC DERIVATIVES, METHOD FOR THEIR PREPARATION AND FUNGICIDES CONTAINING THEM AS ACTIVE INGREDIENTS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-01-29 | — | — | EP | disclosed |
| US-5045554-A | Fluoro compounds, rice sheath blight, Basidiomycetes type fungus | MONSANTO COMPANY (US) | 1991-09-03 | — | — | US | disclosed |
| US-5004816-A | Aminopyrrole intermediates for fungicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-04-02 | — | — | US | disclosed |
| EP-0371950-A2 | Substituted thiazoles and their use as fungicides | Monsanto Company (US) | 1990-06-06 | — | — | EP | disclosed |
| US-4877441-A | 4-ACETAMINOPHTHALIDES | SUMITOMO CHEMICAL COMPANY LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| US-4837242-A | Thiazoles and pyrazoles as fungicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-06-06 | — | — | US | disclosed |
| EP-0315502-A1 | Substituted carboxylic acid derivatives, processes for preparing the same and agricultural or horticultural fungicides containing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-05-10 | — | — | EP | disclosed |
| EP-0276177-A1 | Heterocyclic derivatives, method for their preparation and fungicides containing them as active ingredients | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1988-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12264147-B2 | Substituted carboxamides as inhibitors of WDR5 protein-protein binding | WDR5, WDR82, WDR1 | MAPT 2234/4885ALDH1A1 3236/4885POLB 3553/4885 |
| US-20230219926-A1 | SUBSTITUTED CARBOXAMIDES AS INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | WDR5, WDR82, WDR1 | MAPT 2234/4885ALDH1A1 3236/4885POLB 3553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.