Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873879 | 0.82 | GPR35 (0.43) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL20782350 | 0.81 | CDK8 (0.37) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2310145 | 0.81 | MEN1 (0.49) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL6137447 | 0.81 | MAPT (0.37) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL28070522 | 0.79 | ALDH1A1 (0.41) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2199155 | 0.79 | MAPT (0.56) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL27993175 | 0.75 | MAPT (0.37) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL12271450 | 0.74 | MAPT (0.35) | MAPTALDH1A1POLBHSD11B1 | |
| SCHEMBL20782343 | 0.73 | — | — | |
| SCHEMBL299362 | 0.73 | ALDH1A1 (0.52) | MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107652250-B | Thiazole amide compounds, and preparation method and application thereof | 湖南化工研究院有限公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-105753808-B | Thiazole amide compounds, and preparation method and application thereof | 湖南化工研究院有限公司 | 2018-06-05 | — | — | CN | disclosed |
| CN-107652250-A | Thiazole amide compound and preparation method and application | 湖南化工研究院有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-105753808-A | Thiazole amide compounds, and preparation method and application thereof | 湖南化工研究院有限公司 | 2016-07-13 | — | — | CN | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |