SCHEMBL21996575

SCHEMBL21996575

Fc1ccc(-c2cc3c(NCCc4c[nH]c5ccccc45)ncnc3s2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.53
MAPT P10636 1/20 0.53
MAPK1 P28482 1/20 0.53
HTT P42858 1/20 0.53
GFER P55789 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
FGFR1 P11362 2/20 0.53
PDPK1 O15530 1/20 0.52
RPS6KB1 P23443 1/20 0.52
KDM4E B2RXH2 4/20 0.52
ALDH1A1 P00352 3/20 0.52
RCE1 Q9Y256 1/20 0.52
RAD52 P43351 2/20 0.51
POLB P06746 1/20 0.51
HPGD P15428 1/20 0.48
MEN1 O00255 5/20 0.48
KMT2A Q03164 5/20 0.48
CDK4 P11802 2/20 0.48
CCND1 P24385 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30162756 1.00 LMNA (0.53) LMNAMAPTMAPK1HTTGFER
SCHEMBL24685193 0.88 FDPS (0.50) LMNAFGFR1KDM4EALDH1A1RCE1
SCHEMBL3938271 0.85 TYK2 (0.54) LMNAMAPTMAPK1HTTGFER
SCHEMBL3937743 0.81 TYK2 (0.51) LMNAMAPTMAPK1HTTGFER
SCHEMBL30162626 0.76 ALDH1A1 (0.52) LMNAMAPTMAPK1HTTGFER
SCHEMBL21996574 0.76 ALDH1A1 (0.52) LMNAMAPTMAPK1HTTGFER
SCHEMBL27319374 0.74 GBA1 (0.49) LMNAMAPTMAPK1HTTGFER
SCHEMBL31534058 0.74 GBA1 (0.49) LMNAMAPTMAPK1HTTGFER
SCHEMBL4066406 0.74 LMNA (0.53) LMNAMAPTMAPK1HTTGFER
SCHEMBL6266725 0.73 MAPT (0.49) LMNAMAPTMAPK1HTTGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230028680-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS CELULARITY INC. (US) 2023-01-26 US claimed
US-20220251104-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS CELULARITY INC. (US) 2022-08-11 US claimed
EP-3887364-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS Celularity Inc. (US) 2021-10-06 EP claimed
WO-2020113178-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS Celularity, Inc. (US) 2020-06-04 WO claimed
US-20250295776-A1 CLEAVAGE RESISTANT CD16 CONSTRUCTS AND USES THEREOF CELULARITY INC. (US) 2025-09-25 US disclosed
US-20250276063-A1 PLACENTA-DERVIED NK CELLS AS A SENOL YTIC FOR THERAPEUTIC AND OTHER USES CELULARITY INC. (US) 2025-09-04 US disclosed
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2023-11-09 US disclosed
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2023-11-09 US disclosed
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2023-11-09 US disclosed
WO-2023010123-A1 PLACENTA-DERVIED NK CELLS AS A SENOLYTIC FOR THERAPEUTIC AND OTHER USES CELULARITY INC. (US) 2023-02-02 WO disclosed
WO-2023010123-A1 PLACENTA-DERVIED NK CELLS AS A SENOLYTIC FOR THERAPEUTIC AND OTHER USES CELULARITY INC. (US) 2023-02-02 WO disclosed
US-20230028680-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS CELULARITY INC. (US) 2023-01-26 US disclosed
WO-2021022229-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2021-02-04 WO disclosed
WO-2021022229-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2021-02-04 WO disclosed
WO-2021016621-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CD38 CHIMERIC ANTIGEN RECEPTOR CELULARITY INC. (US) 2021-01-28 WO disclosed
WO-2020252464-A1 POPULATIONS OF NATURAL KILLER CELLS FOR TREATING CANCERS CELULARITY INC. (US) 2020-12-17 WO disclosed
WO-2020252464-A1 POPULATIONS OF NATURAL KILLER CELLS FOR TREATING CANCERS CELULARITY INC. (US) 2020-12-17 WO disclosed
WO-2020113178-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS Celularity, Inc. (US) 2020-06-04 WO disclosed
WO-2020113182-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS Celularity, Inc. (US) 2020-06-04 WO disclosed
WO-2020113182-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS Celularity, Inc. (US) 2020-06-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250295776-A1 CLEAVAGE RESISTANT CD16 CONSTRUCTS AND USES THEREOF PBK, PIGK, CD74 LMNA 742/4885MAPT 4275/4885MAPK1 3371/4885
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 PBK, KLKB1, PIGK LMNA 478/4885MAPT 4385/4885MAPK1 4645/4885
US-20230028680-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS PBK, ILF3, NFATC1 LMNA 1598/4885MAPT 4225/4885MAPK1 2133/4885
US-20220251104-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS ALPP, MCL1, NFATC1 LMNA 3390/4885MAPT 4444/4885MAPK1 2857/4885
US-20250276063-A1 PLACENTA-DERVIED NK CELLS AS A SENOL YTIC FOR THERAPEUTIC AND OTHER USES PBK, CD47, GZMB LMNA 1170/4885MAPT 3342/4885MAPK1 4217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.