SCHEMBL21996574

SCHEMBL21996574

Cc1nc(NCCc2c[nH]c3ccccc23)c2cc(-c3ccccc3)sc2n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
KDM4E B2RXH2 3/20 0.52
GBA1 P04062 1/20 0.52
KMT2A Q03164 5/20 0.50
HTR6 P50406 3/20 0.50
FGFR1 P11362 1/20 0.50
POLB P06746 1/20 0.50
SLC2A1 P11166 1/20 0.50
RAD52 P43351 1/20 0.50
MEN1 O00255 4/20 0.49
LMNA P02545 4/20 0.49
USP2 O75604 3/20 0.49
CYP1A2 P05177 3/20 0.49
CYP3A4 P08684 3/20 0.49
CYP2D6 P10635 3/20 0.49
CYP2C9 P11712 3/20 0.49
CYP2C19 P33261 3/20 0.49
MAPT P10636 2/20 0.49
MAPK1 P28482 2/20 0.49
TP53 P04637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30162626 1.00 ALDH1A1 (0.52) ALDH1A1KDM4EGBA1KMT2AHTR6
SCHEMBL24684887 0.91 FGFR1 (0.48) ALDH1A1KDM4EGBA1KMT2AHTR6
SCHEMBL30162756 0.76 LMNA (0.53) ALDH1A1KDM4EKMT2AFGFR1POLB
SCHEMBL21996575 0.76 LMNA (0.53) ALDH1A1KDM4EKMT2AFGFR1POLB
Bromide SCHEMBL6032392 0.72 MAOA (0.55) ALDH1A1KDM4EGBA1KMT2AHTR6
SCHEMBL4067717 0.72 FLT1 (0.54) ALDH1A1GBA1KMT2AHTR6POLB
SCHEMBL24689903 0.71 GBA1 (0.70) ALDH1A1KDM4EGBA1KMT2APOLB
SCHEMBL6599683 0.70 HTR2A (0.71) ALDH1A1KDM4EKMT2AHTR6POLB
SCHEMBL10028420 0.70 ALDH1A1 (0.54) ALDH1A1KDM4EGBA1KMT2AFGFR1
SCHEMBL20267087 0.70 KMT2A (0.67) ALDH1A1KDM4EGBA1KMT2AHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230028680-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS CELULARITY INC. (US) 2023-01-26 US claimed
US-20220251104-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS CELULARITY INC. (US) 2022-08-11 US claimed
EP-3887364-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS Celularity Inc. (US) 2021-10-06 EP claimed
CN-113454076-A Aromatic compounds for activating hematopoietic stem and progenitor cells 细胞结构公司 2021-09-28 CN claimed
CN-113454207-A Expansion of natural killer cells and ILC3 cells with novel aromatic compounds 细胞结构公司 2021-09-28 CN claimed
WO-2020113178-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS Celularity, Inc. (US) 2020-06-04 WO claimed
US-20250295776-A1 CLEAVAGE RESISTANT CD16 CONSTRUCTS AND USES THEREOF CELULARITY INC. (US) 2025-09-25 US disclosed
US-20250276063-A1 PLACENTA-DERVIED NK CELLS AS A SENOL YTIC FOR THERAPEUTIC AND OTHER USES CELULARITY INC. (US) 2025-09-04 US disclosed
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2023-11-09 US disclosed
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2023-11-09 US disclosed
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2023-11-09 US disclosed
WO-2023010123-A1 PLACENTA-DERVIED NK CELLS AS A SENOLYTIC FOR THERAPEUTIC AND OTHER USES CELULARITY INC. (US) 2023-02-02 WO disclosed
WO-2023010123-A1 PLACENTA-DERVIED NK CELLS AS A SENOLYTIC FOR THERAPEUTIC AND OTHER USES CELULARITY INC. (US) 2023-02-02 WO disclosed
WO-2021022229-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2021-02-04 WO disclosed
WO-2021022229-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 CELULARITY INC. (US) 2021-02-04 WO disclosed
WO-2020252464-A1 POPULATIONS OF NATURAL KILLER CELLS FOR TREATING CANCERS CELULARITY INC. (US) 2020-12-17 WO disclosed
WO-2020252464-A1 POPULATIONS OF NATURAL KILLER CELLS FOR TREATING CANCERS CELULARITY INC. (US) 2020-12-17 WO disclosed
WO-2020113182-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS Celularity, Inc. (US) 2020-06-04 WO disclosed
WO-2020113178-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS Celularity, Inc. (US) 2020-06-04 WO disclosed
WO-2020113182-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS Celularity, Inc. (US) 2020-06-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250295776-A1 CLEAVAGE RESISTANT CD16 CONSTRUCTS AND USES THEREOF PBK, PIGK, CD74 ALDH1A1 4671/4885KDM4E 4569/4885GBA1 2518/4885
US-20230355759-A1 POPULATIONS OF NATURAL KILLER CELLS COMPRISING A CLEAVAGE RESISTANT CD16 PBK, KLKB1, PIGK ALDH1A1 2278/4885KDM4E 2503/4885GBA1 962/4885
US-20230028680-A1 EXPANSION OF NATURAL KILLER CELLS AND ILC3 CELLS WITH NOVEL AROMATIC COMPOUNDS PBK, ILF3, NFATC1 ALDH1A1 458/4885KDM4E 1438/4885GBA1 4011/4885
US-20220251104-A1 AROMATIC COMPOUNDS FOR USE IN ACTIVATING HEMATOPOIETIC STEM AND PROGENITOR CELLS ALPP, MCL1, NFATC1 ALDH1A1 53/4885KDM4E 1093/4885GBA1 4613/4885
US-20250276063-A1 PLACENTA-DERVIED NK CELLS AS A SENOL YTIC FOR THERAPEUTIC AND OTHER USES PBK, CD47, GZMB ALDH1A1 3849/4885KDM4E 574/4885GBA1 1032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.