Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | WDR5 | P61964 | 6/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22004184 | 0.81 | GABRA1 (0.34) | GABRA1GABRB1CYP1A2CYP2C19 | |
| SCHEMBL21883610 | 0.80 | IDO1 (0.34) | GABRA1GABRB1ACLYCYP1A2CYP2C9 | |
| SCHEMBL22005121 | 0.80 | TTR (0.37) | GABRA1GABRB1ACLYMEN1KMT2A | |
| SCHEMBL9967745 | 0.78 | GABRA1 (0.72) | GABRA1GABRB1WDR5MEN1KMT2A | |
| SCHEMBL22028461 | 0.76 | ALDH1A1 (0.38) | MEN1KMT2AMAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL22005122 | 0.75 | LMNA (0.44) | ACLYMEN1KMT2AHSD17B10ESR1 | |
| SCHEMBL631530 | 0.72 | RORC (0.45) | GABRA1GABRB1MEN1KMT2AMAPT | |
| SCHEMBL30395710 | 0.72 | RORC (0.45) | GABRA1GABRB1MEN1KMT2AMAPT | |
| SCHEMBL19780142 | 0.72 | GABRA1 (0.41) | GABRA1GABRB1CYP1A2HIF1ATSHR | |
| SCHEMBL26771218 | 0.72 | LMNA (0.44) | GABRA1GABRB1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | GABRA1 2555/4885GABRB1 1643/4885WDR5 1721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.