Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 6/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844279 | 0.77 | KMO (0.55) | KMOKDM4EMAPTCDK2MEN1 | |
| SCHEMBL14526063 | 0.76 | MAPT (0.51) | KMOKDM4EALDH1A1MAPTCDK2 | |
| SCHEMBL17826991 | 0.74 | KMO (0.55) | KMOMAPTMAP4K4 | |
| SCHEMBL10490481 | 0.74 | MEN1 (0.53) | KDM4EPOLBALDH1A1TRPV3MAPT | |
| SCHEMBL21087455 | 0.74 | DHFR (0.39) | — | |
| SCHEMBL10272516 | 0.72 | AURKA (0.53) | KDM4EPOLBALDH1A1MAPK1MAPT | |
| SCHEMBL16526773 | 0.72 | ASIC3 (0.42) | MAPKAPK2MAPKAPK3MAP4K4 | |
| SCHEMBL16629561 | 0.71 | KMO (0.58) | KMOKDM4EALDH1A1TRPV3CDK2 | |
| SCHEMBL2759537 | 0.70 | HSP90AA1 (0.58) | KDM4EALDH1A1HPGD | |
| SCHEMBL10490263 | 0.70 | TRPV3 (0.37) | KDM4EPOLBALDH1A1TRPV3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662189-B2 | PDE4 inhibitor | Shijiazhuang Sagacity New Drug Development Co., Ltd. (CN) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662189-B2 | PDE4 inhibitor | PDE4A, PDE12, PDE4B | KMO 3379/4885ESR1 4661/4885ESR2 3851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.