Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRB | P28702 | 3/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | F7 | P08709 | 3/20 | 0.31 |
| ▸ | METAP2 | P50579 | 2/20 | 0.31 |
| ▸ | NQO1 | P15559 | 2/20 | 0.31 |
| ▸ | F3 | P13726 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962236 | 0.80 | KMT2A (0.39) | RXRARXRBRXRGMETAP2KMT2A | |
| SCHEMBL25067101 | 0.80 | KMT2A (0.39) | RXRARXRBRXRGMETAP2KMT2A | |
| SCHEMBL21962077 | 0.72 | RXRB (0.43) | RXRARXRBRXRGMETAP2LMNA | |
| SCHEMBL22014435 | 0.70 | POLB (0.36) | RXRARXRBRXRGMETAP2NQO1 | |
| SCHEMBL21962126 | 0.70 | MEN1 (0.39) | RXRARXRBRXRGMETAP2NQO1 | |
| SCHEMBL21962078 | 0.67 | MTNR1A (0.45) | RXRARXRBRXRGMETAP2TSHR | |
| SCHEMBL25033972 | 0.60 | NLRP3 (0.40) | — | |
| SCHEMBL28153404 | 0.58 | NOS1 (0.39) | SMN1; SMN2 | |
| SCHEMBL21500405 | 0.58 | PARP1 (0.44) | TSHR | |
| SCHEMBL23692355 | 0.57 | ALDH1A1 (0.35) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |