Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18931501 | 0.76 | CYP1A2 (0.43) | HSD17B10CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL8250205 | 0.76 | CYP1A2 (0.55) | HSD17B10CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL693428 | 0.75 | HSD17B10 (0.64) | HSD17B10CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL17003209 | 0.75 | HSD17B10 (0.64) | HSD17B10CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL240725 | 0.75 | AAK1 (0.48) | HSD17B10CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL20878760 | 0.73 | KMT2A (0.59) | CYP1A2CYP2D6ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL5998675 | 0.72 | L3MBTL1 (0.48) | HSD17B10CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL478673 | 0.71 | TSHR (0.48) | HSD17B10CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL3242580 | 0.71 | MAPT (0.56) | CYP1A2CYP2D6ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL27745487 | 0.71 | LMNA (0.54) | ALDH1A1SMN1; SMN2RAB9APOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | HSD17B10 1037/4885CYP1A2 185/4885CYP2D6 251/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | HSD17B10 1037/4885CYP1A2 185/4885CYP2D6 251/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | HSD17B10 1037/4885CYP1A2 185/4885CYP2D6 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.