Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12432447 | 0.98 | MAPT (0.56) | MAPTLMNAHTTHDAC4HDAC2 | |
| SCHEMBL12432444 | 0.90 | MAPT (0.65) | MAPTLMNAHTTHDAC4HDAC2 | |
| SCHEMBL12173542 | 0.82 | MAPT (0.41) | MAPTLMNAHTTHDAC4HDAC2 | |
| Biphenyl SCHEMBL5711843 | 0.81 | ALDH1A1 (0.53) | MAPTLMNAHTTHDAC4HDAC2 | |
| SCHEMBL18392174 | 0.81 | HTT (0.88) | MAPTLMNAHTTHDAC4HDAC2 | |
| SCHEMBL4458298 | 0.79 | HDAC4 (0.54) | MAPTLMNAHTTHDAC4HDAC2 | |
| SCHEMBL14438402 | 0.79 | NR3C2 (0.40) | MAPTLMNAHTTHDAC4HDAC2 | |
| SCHEMBL1109016 | 0.76 | CYP3A4 (0.43) | MAPTKMT2AKDM4EPOLBGAA | |
| SCHEMBL2202541 | 0.76 | SERPINE1 (0.42) | MAPTSMN1; SMN2KDM4EGAAABCB1 | |
| SCHEMBL12432628 | 0.76 | ALOX12 (0.42) | LMNAHTTKMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200303660-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-09-24 | — | — | US | disclosed |
| US-10333079-B2 | Organic photosensitive devices comprising aryl squaraines and methods of making the same | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2019-06-25 | — | — | US | disclosed |
| US-20160005983-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-01-07 | — | — | US | disclosed |
| US-20160005983-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-01-07 | — | — | US | disclosed |
| US-20120248419-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | ENERGY, UNITED STATES DEPARTMENT OF | 2012-10-04 | — | — | US | disclosed |
| US-20120248419-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | ENERGY, UNITED STATES DEPARTMENT OF | 2012-10-04 | — | — | US | disclosed |
| US-7977393-B2 | Composition containing oxocarbon and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977393-B2 | Composition containing oxocarbon and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977393-B2 | Composition containing oxocarbon and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7906548-B2 | Methods for the use of inhibitors of cytosolic phospholipase A2 | WYETH LLC (US) | 2011-03-15 | — | — | US | disclosed |
| US-20080009485-A1 | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis | WYETH (US) | 2008-01-10 | — | — | US | disclosed |
| US-20080009485-A1 | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis | WYETH (US) | 2008-01-10 | — | — | US | disclosed |
| EP-1845135-A1 | COMPOSITION CONTAINING OXOCARBON AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2007-10-17 | — | — | EP | disclosed |
| US-20070218335-A1 | POLYMER HAVING OXOCARBON GROUP, AND USE THEREOF | KAO CORPORATION (JP) | 2007-09-20 | — | — | US | disclosed |
| US-20070141630-A1 | IDENTIFICATION OF NON-COVALENT COMPLEXES BY MASS SPECTROMETRY | GENENTECH, INC. (US) | 2007-06-21 | — | — | US | disclosed |
| US-20070141630-A1 | IDENTIFICATION OF NON-COVALENT COMPLEXES BY MASS SPECTROMETRY | GENENTECH, INC. (US) | 2007-06-21 | — | — | US | disclosed |
| EP-1741740-A1 | POLYMER HAVING OXOCARBON GROUP AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| US-4986935-A | NONLINEAR OPTICAL DEVICES; COMPOUND HAVING HIGH ACTIVITY FOR SECOND HARMONIC WAVE GENERATION | FUJI XEROX CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| US-4751327-A | Photoconductive imaging members with unsymmetrical squaraine compounds | XEROX CORPORATION (US) | 1988-06-14 | — | — | US | disclosed |
| US-4624904-A | Photoconductive imaging members with unsymmetrical squaraine compounds containing an hydroxyl group | XEROX CORPORATION (US) | 1986-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160005983-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | TYR, SQLE, SPIN3 | MAPT 4099/4885LMNA 4334/4885HTT 3337/4885 |
| US-20080009485-A1 | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis | PLA2G12A, PLA2G1B, PLA2G5 | MAPT 4878/4885LMNA 1353/4885HTT 3375/4885 |
| US-20120248419-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | TYR, SQLE, SPIN3 | MAPT 4099/4885LMNA 4334/4885HTT 3337/4885 |
| US-10333079-B2 | Organic photosensitive devices comprising aryl squaraines and methods of making the same | TYR, SQLE, SPIN3 | MAPT 4099/4885LMNA 4334/4885HTT 3337/4885 |
| US-20200303660-A1 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME | TYR, SQLE, SPIN3 | MAPT 4099/4885LMNA 4334/4885HTT 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.