Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 9/20 | 0.48 |
| ▸ | DRD2 | P14416 | 9/20 | 0.48 |
| ▸ | HTR2A | P28223 | 9/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22048856 | 0.92 | HTR2A (0.45) | PLK1CSNK2A1PLK3HTR1ADRD2 | |
| SCHEMBL9220615 | 0.72 | PLK1 (0.53) | PLK1CSNK2A1PLK3HTR1ADRD2 | |
| SCHEMBL3143484 | 0.69 | PLK1 (0.49) | PLK1CSNK2A1PLK3HTR1ADRD2 | |
| SCHEMBL9533936 | 0.68 | PLK1 (0.74) | PLK1CSNK2A1PLK3HTR1ADRD2 | |
| SCHEMBL3142557 | 0.68 | PLK1 (0.93) | PLK1CSNK2A1PLK3HTR1ADRD2 | |
| SCHEMBL1986758 | 0.68 | PLK1 (1.00) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL8875391 | 0.67 | ACHE (0.53) | HTR1ASIGMAR1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.66 | PLK1 (0.59) | PLK1CSNK2A1PLK3HTR1ADRD2 | |
| SCHEMBL9218236 | 0.66 | PLK1 (0.47) | PLK1CSNK2A1PLK3HTR1ADRD2 | |
| SCHEMBL9535703 | 0.64 | PLK1 (0.61) | PLK1CSNK2A1PLK3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2023-01-12 | — | — | US | disclosed |
| US-10745401-B2 | Condensed lactam derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-18 | — | — | US | disclosed |
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-13 | — | — | US | disclosed |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | PLK1 443/4885CSNK2A1 100/4885PLK3 2718/4885 |
| US-10745401-B2 | Condensed lactam derivative | PSEN1, GRIN1, HDAC1 | PLK1 443/4885CSNK2A1 100/4885PLK3 2718/4885 |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | HTR1A, HTR5A, TPH1 | PLK1 1447/4885CSNK2A1 1326/4885PLK3 2881/4885 |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | PLK1 443/4885CSNK2A1 100/4885PLK3 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.