SCHEMBL22055802

SCHEMBL22055802

CON1CCC[C@H]1c1cccc(C)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
GAA P10253 1/20 0.46
MAOB P27338 2/20 0.46
DRD2 P14416 1/20 0.46
DRD1 P21728 1/20 0.46
DRD4 P21917 1/20 0.46
DRD5 P21918 1/20 0.46
DRD3 P35462 1/20 0.46
MAPK1 P28482 1/20 0.43
MAOA P21397 1/20 0.43
ROCK2 O75116 1/20 0.42
HTR2C P28335 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
CHRNB2 P17787 1/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA7 P36544 1/20 0.40
CHRNA4 P43681 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13162103 0.79 CHRNB2 (0.66) ALDH1A1MAPTCHRNB2CHRNB4CHRNA3
SCHEMBL9273128 0.77 CHRNB2 (0.53) MAOBMAOACHRNB2CHRNB4CHRNA3
SCHEMBL6560857 0.76 RIPK1 (0.42) ALDH1A1GAAMAOBDRD2DRD4
SCHEMBL24775490 0.75 DRD2 (0.46) ALDH1A1MAOBDRD2DRD1DRD4
SCHEMBL27111350 0.75 DRD2 (0.46) ALDH1A1MAOBDRD2DRD1DRD4
SCHEMBL24775063 0.75 DRD2 (0.46) ALDH1A1GAAMAOBDRD2DRD1
SCHEMBL14948763 0.74 CHRNB2 (0.59) ALDH1A1MAOBDRD2DRD1DRD4
Hydrochloric Acid SCHEMBL28938994 0.73 ALDH1A1 (0.47) ALDH1A1GAAMAOBDRD2DRD1
SCHEMBL6560000 0.72 PRMT5 (0.40) ALDH1A1MAOBDRD2DRD4DRD3
SCHEMBL21034433 0.72 TRPA1 (0.45) ALDH1A1GAAMAOBDRD2DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3209664-B1 BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-06-03 EP disclosed