Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22075550 | 0.95 | KDM4E (0.54) | KDM4EHPGDKMT2AGAAGLA | |
| SCHEMBL18073970 | 0.83 | KDM4E (0.55) | KDM4EHPGDKMT2AGAAGLA | |
| SCHEMBL15984890 | 0.74 | KDM4E (0.64) | KDM4EHPGDKMT2AGAAGLA | |
| SCHEMBL10144071 | 0.74 | KDM4E (0.60) | KDM4EHPGDKMT2AGAAHSD17B10 | |
| SCHEMBL18074001 | 0.73 | KDM4E (0.62) | KDM4EHPGDKMT2AGAAGLA | |
| SCHEMBL19999164 | 0.72 | ALOX15 (0.54) | KDM4EKMT2ALMNAMAPK1MAPT | |
| SCHEMBL11307503 | 0.72 | KDM4E (0.84) | KDM4EHPGDKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL21043909 | 0.71 | ALDH1A1 (0.52) | KDM4EHPGDKMT2AGAAGLA | |
| SCHEMBL6265896 | 0.71 | KDM4E (0.61) | KDM4EHPGDKMT2AGAAGLA | |
| SCHEMBL6264833 | 0.71 | KDM4E (0.61) | KDM4EHPGDKMT2AGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11396499-B2 | Lysosomal acid lipase assay | UNIVERSITY OF WASHINGTON (US) | 2022-07-26 | — | — | US | claimed |
| US-20200190050-A1 | LYSOSOMAL ACID LIPASE ASSAY | UNIVERSITY OF WASHINGTON (US) | 2020-06-18 | — | — | US | claimed |
| US-11396499-B2 | Lysosomal acid lipase assay | UNIVERSITY OF WASHINGTON (US) | 2022-07-26 | — | — | US | disclosed |
| US-20200190050-A1 | LYSOSOMAL ACID LIPASE ASSAY | UNIVERSITY OF WASHINGTON (US) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11396499-B2 | Lysosomal acid lipase assay | LIPA, LPL, PNLIP | KDM4E 4408/4885HPGD 1589/4885KMT2A 3596/4885 |
| US-20200190050-A1 | LYSOSOMAL ACID LIPASE ASSAY | LIPA, LPL, PNLIP | KDM4E 4408/4885HPGD 1589/4885KMT2A 3596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.