Mertansine

Mertansine

SCHEMBL22097295

COc1cc2cc(c1Cl)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCS)[C@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](OC)/C=C\C=C(/C)C2

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB4A P04350 4/20 0.87
▸ TUBB P07437 4/20 0.87
▸ TUBA3C P0DPH7 4/20 0.87
▸ TUBA1B P68363 4/20 0.87
▸ TUBA4A P68366 4/20 0.87
▸ TUBB4B P68371 4/20 0.87
▸ TUBB3 Q13509 4/20 0.87
▸ TUBB2A Q13885 4/20 0.87
▸ TUBB8 Q3ZCM7 4/20 0.87
▸ TUBA3E Q6PEY2 4/20 0.87
▸ TUBA1A Q71U36 4/20 0.87
▸ TUBA1C Q9BQE3 4/20 0.87
▸ TUBB6 Q9BUF5 4/20 0.87
▸ TUBB2B Q9BVA1 4/20 0.87
▸ TUBB1 Q9H4B7 4/20 0.87
▸ CYP2D6 P10635 1/20 0.83
▸ TSHR P16473 1/20 0.83
▸ CYP2C19 P33261 1/20 0.83
▸ HIF1A Q16665 1/20 0.83
▸ P4HB P07237 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mertansine SCHEMBL21095214 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL24235209 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL22762724 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL24776847 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL24917414 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL24823366 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL24336892 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL23140493 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL22580840 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Mertansine SCHEMBL17754556 1.00 TUBB4A (0.87) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230041661-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 BICYCLETX LIMITED (GB) 2023-02-09 — — US disclosed
US-20230033370-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 BICYCLETX LIMITED (GB) 2023-02-02 — — US disclosed
US-20230021419-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 BICYCLETX LIMITED (GB) 2023-01-26 — — US disclosed
US-20220133733-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CD38 BICYCLERD LTD (GB) 2022-05-05 — — US disclosed
US-20220133732-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CAIX BICYCLERD LTD (GB) 2022-05-05 — — US disclosed
WO-2022079445-A1 BICYCLIC PEPTIDE LIGAND DRUG CONJUGATES Bicyclerd Limited (GB) 2022-04-21 — — WO disclosed
US-20220064218-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CD38 BICYCLETX LIMITED (GB) 2022-03-03 — — US disclosed
US-20220024983-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 Bicyclerd Limited (GB) 2022-01-27 — — US disclosed
US-20220024982-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP BICYCLETX LIMITED (GB) 2022-01-27 — — US disclosed
US-20220008545-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR FAPa Bicyclerd Limited (GB) 2022-01-13 — — US disclosed
WO-2020148530-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CD38 Bicyclerd Limited (GB) 2020-07-23 — — WO disclosed
WO-2020148526-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CAIX Bicyclerd Limited (GB) 2020-07-23 — — WO disclosed
WO-2020128526-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PD-L1 BICYCLETX LIMITED (GB) 2020-06-25 — — WO disclosed
WO-2020128527-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PD-L1 Bicyclerd Limited (GB) 2020-06-25 — — WO disclosed
WO-2020120984-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP BICYCLETX LIMITED (GB) 2020-06-18 — — WO disclosed
WO-2020120978-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 Bicyclerd Limited (GB) 2020-06-18 — — WO disclosed
WO-2020120981-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP BICYCLETX LIMITED (GB) 2020-06-18 — — WO disclosed
WO-2020120979-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR FAPα Bicyclerd Limited (GB) 2020-06-18 — — WO disclosed
WO-2020120983-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP Bicyclerd Limited (GB) 2020-06-18 — — WO disclosed
WO-2020120980-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PSMA Bicyclerd Limited (GB) 2020-06-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220064218-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CD38 CD38, CD22, CD40LG TUBB4A 4324/4885TUBB 4234/4885TUBA3C 3716/4885
US-20220024982-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP MMEL1, MMP3, TIMP3 TUBB4A 2397/4885TUBB 2117/4885TUBA3C 1040/4885
US-20220008545-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR FAPa FAP, FIBP, FGFR3 TUBB4A 2762/4885TUBB 3294/4885TUBA3C 3074/4885
US-20230041661-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 IL17A, IL23R, IL15 TUBB4A 2707/4885TUBB 1777/4885TUBA3C 1355/4885
US-20220133733-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CD38 CD38, CD22, TIMCC TUBB4A 4364/4885TUBB 4236/4885TUBA3C 3344/4885
US-20220024983-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 IL17A, IL23R, IL15 TUBB4A 2352/4885TUBB 1482/4885TUBA3C 1085/4885
US-20230021419-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 IL17A, IL23R, IL15 TUBB4A 2707/4885TUBB 1777/4885TUBA3C 1355/4885
US-20220133732-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CAIX CA4, CA2, CA13 TUBB4A 3712/4885TUBB 3940/4885TUBA3C 3270/4885
US-20230033370-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR IL-17 IL17A, IL23R, IL15 TUBB4A 2707/4885TUBB 1777/4885TUBA3C 1355/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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