Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271034 | 0.79 | TRPM8 (1.00) | TRPM8ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL14099270 | 0.69 | ALDH1A1 (0.48) | TRPM8ALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL22100808 | 0.67 | TRPM8 (1.00) | TRPM8ALDH1A1KDM4EPOLBNFE2L2 | |
| SCHEMBL10271037 | 0.67 | TRPM8 (1.00) | TRPM8ALDH1A1KDM4EPOLBNFE2L2 | |
| SCHEMBL6296360 | 0.63 | KRAS (0.67) | TRPM8ALDH1A1KDM4ELMNANFE2L2 | |
| SCHEMBL6296362 | 0.63 | KRAS (0.67) | TRPM8ALDH1A1KDM4ELMNANFE2L2 | |
| SCHEMBL118591 | 0.63 | NFE2L2 (0.79) | KDM4ENFE2L2MAPTHSD17B10MEN1 | |
| SCHEMBL615385 | 0.62 | NFE2L2 (0.77) | KDM4ENFE2L2MAPTHSD17B10 | |
| SCHEMBL18634171 | 0.62 | NFE2L2 (0.56) | TRPM8ALDH1A1NFE2L2MAPTKMT2A | |
| SCHEMBL14139451 | 0.61 | LCK (0.58) | TRPM8ALDH1A1LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |