Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.57 |
| ▸ | BRD4 | O60885 | 10/20 | 0.52 |
| ▸ | BRD2 | P25440 | 2/20 | 0.52 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.52 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454403 | 0.85 | PDE4A (0.61) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL22105714 | 0.85 | PDE4A (0.55) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL516463 | 0.79 | PDE4A (0.81) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9565477 | 0.77 | PDE4A (0.65) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7464482 | 0.76 | PDE4A (0.86) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7031729 | 0.74 | MEN1 (0.87) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL21381257 | 0.73 | PDE4A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9055277 | 0.73 | PDE4A (0.61) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7465479 | 0.72 | BRD4 (0.76) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL554932 | 0.72 | BRD4 (0.81) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177479-A1 | NOVEL SUBSTITUTED XANTHINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-06-09 | — | — | US | disclosed |
| US-11198696-B2 | Substituted xanthines as inhibitors of transient receptor potential cation channel subfamily c, member 5 activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-12-14 | — | — | US | disclosed |
| US-20200190093-A1 | SUBSTITUTED XANTHINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190093-A1 | SUBSTITUTED XANTHINE DERIVATIVES | TRPC5, TRPC4, TRPM5 | PDE4A 756/4885ADORA2A 178/4885PDE4B 718/4885 |
| US-11198696-B2 | Substituted xanthines as inhibitors of transient receptor potential cation channel subfamily c, member 5 activity | TRPC5, TRPM5, TRPC4 | PDE4A 682/4885ADORA2A 223/4885PDE4B 717/4885 |
| US-20220177479-A1 | NOVEL SUBSTITUTED XANTHINE DERIVATIVES | TRPC5, TRPC4, TRPM5 | PDE4A 624/4885ADORA2A 263/4885PDE4B 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.