Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | S100A9 | P06702 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MARS1 | P56192 | 1/20 | 0.35 |
| ▸ | CLPP | Q16740 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22118895 | 0.84 | PARP1 (0.40) | PARP1PNPDAORNASEH1PDE5A | |
| SCHEMBL22118862 | 0.84 | PARP1 (0.40) | PARP1PNPDAORNASEH1PDE5A | |
| SCHEMBL22118835 | 0.81 | TSHR (0.42) | PARP1RNASEH1PDE5APDE9APDE1A | |
| SCHEMBL22119321 | 0.78 | PNP (0.40) | PARP1PNPRNASEH1S100A9L3MBTL1 | |
| SCHEMBL22118923 | 0.78 | PDE5A (0.35) | PNPRNASEH1PDE5APDE9APDE1A | |
| SCHEMBL22118800 | 0.70 | CLPP (0.46) | CLPP | |
| SCHEMBL22118979 | 0.70 | CLPP (0.46) | CLPP | |
| SCHEMBL22118843 | 0.69 | ALDH1A1 (0.36) | PARP1PNPALDH1A1 | |
| SCHEMBL8987672 | 0.67 | L3MBTL1 (0.65) | L3MBTL1ALDH1A1 | |
| SCHEMBL6365512 | 0.64 | PDE9A (0.52) | PNPDAORNASEH1PDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897645-A1 | DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF | Acurx Pharmaceuticals, LLC (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132174-A1 | DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF | ACURX PHARMACEUTICALS, LLC (US) | 2020-06-25 | — | — | WO | disclosed |