Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CLPP | Q16740 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22118878 | 0.92 | SIGMAR1 (0.39) | AURKBSIGMAR1KDM4EALDH1A1KCNH2 | |
| SCHEMBL22119381 | 0.85 | RNASEH1 (0.34) | — | |
| SCHEMBL22118854 | 0.85 | RNASEH1 (0.34) | — | |
| SCHEMBL22118859 | 0.83 | RNASEH1 (0.33) | — | |
| SCHEMBL22118943 | 0.83 | PTGES (0.35) | SIGMAR1ALDH1A1CLPP | |
| SCHEMBL22118865 | 0.82 | PNP (0.33) | — | |
| Hydrochloric Acid SCHEMBL22119087 | 0.82 | PNP (0.32) | SIGMAR1 | |
| SCHEMBL22118872 | 0.81 | TSHR (0.36) | ALDH1A1TSHR | |
| SCHEMBL22118816 | 0.81 | PNP (0.31) | — | |
| SCHEMBL22118974 | 0.79 | PNP (0.33) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897645-A1 | DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF | Acurx Pharmaceuticals, LLC (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132174-A1 | DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF | ACURX PHARMACEUTICALS, LLC (US) | 2020-06-25 | — | — | WO | disclosed |