Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716917 | 0.83 | PIK3CA (0.52) | IDH1SYKPIK3CAPIK3CBALDH1A1 | |
| SCHEMBL17149371 | 0.80 | TSHR (0.49) | MEN1KMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4504724 | 0.79 | ABL1 (0.52) | KMT2ACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL19072400 | 0.77 | KMT2A (0.45) | MEN1KMT2AIDH1SYKNQO2 | |
| SCHEMBL3712550 | 0.76 | HCAR3 (0.42) | IDH1SYKNQO2ALDH1A1 | |
| SCHEMBL22148690 | 0.75 | KCNQ3 (0.41) | PIK3CAPIK3CBMAOB | |
| SCHEMBL25389725 | 0.75 | ESR1 (0.46) | IDH1SYKNQO2ALDH1A1 | |
| SCHEMBL512745 | 0.74 | NQO2 (0.44) | SYKNQO2ALDH1A1 | |
| SCHEMBL20814215 | 0.74 | MAPT (0.47) | HIF1APIK3CADHFRALDH1A1CYP1A2 | |
| SCHEMBL27798554 | 0.74 | KMT2A (0.48) | KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098029-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2026-04-09 | — | — | US | disclosed |
| US-12509442-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2025-12-30 | — | — | US | disclosed |
| US-20240317715-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2024-09-26 | — | — | US | disclosed |
| US-12054476-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2024-08-06 | — | — | US | disclosed |
| US-20220106293-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2022-04-07 | — | — | US | disclosed |
| US-11236069-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-11236069-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2022-02-01 | — | — | US | disclosed |
| EP-3897852-A1 | KIF18A INHIBITORS | Amgen Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| CN-113226473-A | KIF18A inhibitors | 美国安进公司 | 2021-08-06 | — | — | CN | disclosed |
| US-20200239441-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-07-30 | — | — | US | disclosed |
| US-20200239441-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-07-30 | — | — | US | disclosed |
| WO-2020132648-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020132648-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509442-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIFC1 | HIF1A 3338/4885MEN1 4116/4885KMT2A 379/4885 |
| US-20240317715-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | HIF1A 1950/4885MEN1 2120/4885KMT2A 381/4885 |
| US-20220106293-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | HIF1A 1950/4885MEN1 2120/4885KMT2A 381/4885 |
| US-20200239441-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | HIF1A 1950/4885MEN1 2120/4885KMT2A 381/4885 |
| US-12054476-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | HIF1A 1950/4885MEN1 2120/4885KMT2A 381/4885 |
| US-20260098029-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIFC1 | HIF1A 3282/4885MEN1 4094/4885KMT2A 383/4885 |
| US-11236069-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | HIF1A 1950/4885MEN1 2120/4885KMT2A 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.