Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | IP6K1 | Q92551 | 6/20 | 0.44 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554348 | 0.88 | HSD11B1 (0.57) | HSD11B1IP6K1IP6K3IP6K2HTR1A | |
| SCHEMBL3837117 | 0.75 | IP6K1 (0.55) | IP6K1IP6K3IP6K2LMNAHTR1A | |
| SCHEMBL31430234 | 0.74 | ADRA2B (0.50) | IP6K1IP6K3IP6K2ADRA2BLMNA | |
| SCHEMBL2213581 | 0.74 | ADRA2B (0.50) | IP6K1IP6K3IP6K2ADRA2BLMNA | |
| SCHEMBL4988173 | 0.73 | IP6K1 (0.58) | IP6K1IP6K3IP6K2ADRA2BLMNA | |
| SCHEMBL4359077 | 0.73 | MGAM (0.53) | IP6K1IP6K3IP6K2MAPTTP53 | |
| SCHEMBL3855796 | 0.73 | IP6K1 (0.45) | IP6K1IP6K3IP6K2ADRA2BLMNA | |
| SCHEMBL3252852 | 0.72 | HRH4 (0.55) | IP6K1IP6K3IP6K2 | |
| SCHEMBL4553174 | 0.72 | HSD11B1 (0.39) | HSD11B1LMNAMAPTALDH1A1TP53 | |
| SCHEMBL8249761 | 0.72 | IP6K1 (0.40) | IP6K1IP6K3IP6K2ADRA2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678806-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| US-20080280898-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-11-13 | — | — | US | claimed |
| EP-2125726-B1 | SPIRO-PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | disclosed |
| EP-2125726-B1 | SPIRO-PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | disclosed |
| US-7678806-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678806-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678806-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| EP-2125726-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| US-7501432-B2 | Spiro-piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501432-B2 | Spiro-piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501432-B2 | Spiro-piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20080280898-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-07-10 | — | — | US | disclosed |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-07-10 | — | — | US | disclosed |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-07-10 | — | — | US | disclosed |
| US-20080161304-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161304-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161304-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| WO-2008077811-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008077811-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161304-A1 | Spiro-piperidine derivatives | AVPR1A, AVPR1B, ADRA1A | HSD11B1 1386/4885IP6K1 2020/4885IP6K3 2630/4885 |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | HTR1A, HTR5A, ADRA1A | HSD11B1 1815/4885IP6K1 2814/4885IP6K3 3366/4885 |
| US-20080280898-A1 | Spiro-piperidine derivatives | AVPR1A, AVPR1B, ADRA1A | HSD11B1 1386/4885IP6K1 2020/4885IP6K3 2630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.