Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 15/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 14/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 14/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.56 |
| ▸ | CFB | P00751 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369306 | 0.76 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL1723548 | 0.73 | ADRA2B (0.84) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL6897370 | 0.72 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL10555827 | 0.71 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL10554892 | 0.71 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL1724062 | 0.71 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1ATSHR | |
| SCHEMBL2214992 | 0.71 | POLB (0.44) | TAAR1CYP1A2 | |
| SCHEMBL2216731 | 0.70 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL13080425 | 0.68 | SLC6A2 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL16421280 | 0.68 | SLC6A2 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| CN-101855213-A | Therapeutic compounds | ALLERGAN INC | 2010-10-06 | — | — | CN | disclosed |
| EP-2188261-A1 | THERAPEUTIC COMPOUNDS | Allergan, Inc. (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009023757-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
| WO-2009023757-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | GOT2, GOT1, ANXA5 | ADRA2A 1550/4885ADRA2B 1943/4885ADRA2C 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.