Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993959 | 0.73 | LMNA (0.49) | POLBLMNA | |
| SCHEMBL12253328 | 0.71 | POLB (0.42) | POLBLMNATAAR1NPC1RAB9A | |
| SCHEMBL2215859 | 0.71 | ADRA2A (0.56) | TAAR1CYP1A2 | |
| SCHEMBL2006482 | 0.70 | RAB9A (0.42) | POLBLMNATAAR1NPC1RAB9A | |
| SCHEMBL12437171 | 0.70 | RAB9A (0.42) | POLBLMNATAAR1NPC1RAB9A | |
| SCHEMBL13080425 | 0.68 | SLC6A2 (0.53) | NPC1RAB9ATP53MAPK1CYP1A2 | |
| SCHEMBL13080424 | 0.68 | SLC6A2 (0.53) | NPC1RAB9ATP53MAPK1CYP1A2 | |
| SCHEMBL16421280 | 0.68 | SLC6A2 (0.53) | NPC1RAB9ATP53MAPK1CYP1A2 | |
| SCHEMBL2797750 | 0.68 | LMNA (0.43) | POLBLMNATAAR1NPC1RAB9A | |
| SCHEMBL4667034 | 0.67 | POLB (0.50) | POLBLMNATAAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101855213-B | Therapeutic compounds | ALLERGAN INC | 2014-09-10 | — | — | CN | disclosed |
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| CN-101855213-A | Therapeutic compounds | ALLERGAN INC | 2010-10-06 | — | — | CN | disclosed |
| EP-2188261-A1 | THERAPEUTIC COMPOUNDS | Allergan, Inc. (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009023757-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
| WO-2009023757-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178143-A1 | THERAPEUTIC COMPOUNDS | GOT2, GOT1, ANXA5 | POLB 2665/4885LMNA 2315/4885TAAR1 4833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.