Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | USP1 | O94782 | 6/20 | 0.47 |
| ▸ | WDR48 | Q8TAF3 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22164114 | 0.84 | USP1 (0.41) | USP1WDR48TP53MCHR1AURKA | |
| SCHEMBL28220529 | 0.79 | HDAC6 (0.61) | NPC1RAB9AHDAC6USP1WDR48 | |
| SCHEMBL14980555 | 0.77 | NPC1 (0.63) | NPC1RAB9AHDAC6KDM4ETP53 | |
| SCHEMBL12175974 | 0.74 | RAD52 (0.64) | USP1WDR48KDM4E | |
| SCHEMBL9921367 | 0.73 | AURKA (0.63) | RAB9AUSP1WDR48HTTSMN1; SMN2 | |
| SCHEMBL19553834 | 0.73 | RAB9A (0.66) | NPC1RAB9AHDAC6KDM4ETP53 | |
| SCHEMBL30885179 | 0.73 | RAB9A (0.66) | NPC1RAB9AHDAC6KDM4ETP53 | |
| SCHEMBL6774198 | 0.72 | MARS1 (0.49) | NPC1RAB9AHDAC6KDM4ETP53 | |
| SCHEMBL22926769 | 0.71 | NPC1 (0.63) | NPC1RAB9AHDAC6KDM4ETP53 | |
| SCHEMBL6089806 | 0.70 | HDAC6 (0.54) | NPC1RAB9AHDAC6KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020136693-A1 | SUBSTITUTED QUINOLONE COMPOUNDS, THEIR USE IN THE TREATMENT OF CANCER, AND A METHOD FOR PREPARATION | UNIVERSITY OF PETRA (JO) | 2020-07-02 | — | — | WO | disclosed |