Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL539890 | 0.84 | LIPE (0.54) | LIPELMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL29950569 | 0.84 | LIPE (0.54) | LIPELMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL29954329 | 0.78 | TUBB4A (0.48) | LIPEENPP2F10LMNAMAOB | |
| SCHEMBL23273767 | 0.77 | MAOB (0.49) | APPF10MAOBMAPT | |
| SCHEMBL8497207 | 0.76 | RXRA (0.59) | FFAR1LMNAMAOBALDH1A1MAPT | |
| SCHEMBL14518225 | 0.76 | LMNA (0.53) | FFAR1APPF10LMNACYP1A2 | |
| SCHEMBL2553220 | 0.74 | ENPP2 (0.51) | FFAR1APPENPP2MAPT | |
| SCHEMBL16295658 | 0.74 | LIPE (0.54) | LIPELMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL177615 | 0.74 | APP (0.58) | LIPEFFAR1APPLMNACYP1A2 | |
| SCHEMBL2560315 | 0.74 | ENPP2 (0.54) | APPENPP2MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696658-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2020-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10696658-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | DRD1, SNCA, DRD2 | LIPE 2282/4885FFAR1 859/4885APP 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.