Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB2 | P49721 | 10/20 | 0.35 |
| ▸ | PSMB10 | P40306 | 9/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.33 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17468562 | 0.91 | ALDH1A1 (0.35) | PSMB2PSMB10ALDH1A1LMNAMAPT | |
| SCHEMBL17834946 | 0.91 | ITGB3 (0.39) | PSMB2PSMB10KIFC1ITGB3ITGA2B | |
| SCHEMBL19485626 | 0.91 | ITGB3 (0.39) | PSMB2PSMB10KIFC1ITGB3ITGA2B | |
| SCHEMBL22167454 | 0.89 | PSMB2 (0.33) | PSMB2PSMB10KLKB1KIFC1MME | |
| SCHEMBL17532335 | 0.89 | PSMB2 (0.33) | PSMB2PSMB10KLKB1KIFC1MME | |
| SCHEMBL22167483 | 0.88 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTKLKB1KIFC1 | |
| SCHEMBL17834855 | 0.86 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTKIFC1MME | |
| SCHEMBL17995453 | 0.85 | ITGB3 (0.40) | PSMB2PSMB10KIFC1ITGB3ITGA2B | |
| SCHEMBL17834935 | 0.85 | ITGB3 (0.40) | PSMB2PSMB10KIFC1ITGB3ITGA2B | |
| SCHEMBL19485605 | 0.85 | ITGB3 (0.40) | PSMB2PSMB10KIFC1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |