Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.30 |
| ▸ | LMNA | P02545 | 3/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HRH1 | P35367 | 2/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | RGS12 | O14924 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22169114 | 0.84 | GAA (0.43) | LMNAMEN1ALDH1A1GAAMAPT | |
| SCHEMBL27890396 | 0.76 | CNR2 (0.36) | CNR2CYP1A2GAAMAPTCYP2C9 | |
| SCHEMBL21848255 | 0.73 | CNR2 (0.36) | CNR2CYP1A2ALDH1A1GAAMAPT | |
| SCHEMBL27932933 | 0.73 | CNR2 (0.39) | CNR2CYP2D6CYP1A2GAAMAPT | |
| SCHEMBL2355308 | 0.73 | MAPT (0.36) | CNR2LMNAALDH1A1GAAMAPT | |
| SCHEMBL27948460 | 0.73 | HTR1A (0.39) | CNR2KDM4EALDH1A1GAAMAPT | |
| Water SCHEMBL27949936 | 0.72 | CNR2 (0.35) | CNR2GAAMAPTCYP2C9CYP2C19 | |
| SCHEMBL5948340 | 0.71 | CNR2 (0.35) | CNR2SLC6A3ALDH1A1GAAMAPT | |
| SCHEMBL30729387 | 0.67 | CHEK1 (0.37) | CNR2HTR2AHRH1CHRM2CHRM1 | |
| SCHEMBL29947345 | 0.67 | DRD4 (0.35) | CNR2CYP2D6CYP1A2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | IDH1, IDH3B, IDH3A | CNR2 4684/4885SLC6A2 4665/4885SLC6A4 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.