Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729387 | 0.78 | CHEK1 (0.37) | DRD4CNR2HRH3 | |
| SCHEMBL21848255 | 0.73 | CNR2 (0.36) | DRD4CNR2CYP1A2CYP2C9 | |
| SCHEMBL27890396 | 0.73 | CNR2 (0.36) | DRD4CNR2CYP1A2CYP2C9 | |
| SCHEMBL27932933 | 0.73 | CNR2 (0.39) | DRD4CNR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27948460 | 0.73 | HTR1A (0.39) | CNR2HRH3PDK1 | |
| SCHEMBL2355308 | 0.73 | MAPT (0.36) | CNR2CYP2C9TSHR | |
| Water SCHEMBL27949936 | 0.72 | CNR2 (0.35) | DRD4CNR2CYP2C9 | |
| SCHEMBL5948340 | 0.71 | CNR2 (0.35) | DRD4CNR2HRH3DRD2DRD3 | |
| SCHEMBL29947262 | 0.69 | KEAP1 (0.41) | DRD4 | |
| SCHEMBL22169108 | 0.67 | CNR2 (0.37) | CNR2CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337206-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | Libra Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240992-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | LIBRA THERAPEUTICS, INC. (US) | 2022-11-17 | — | — | WO | disclosed |