Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GPX4 | P36969 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22176126 | 0.79 | ALDH1A1 (0.41) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22175908 | 0.76 | SIGMAR1 (0.37) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL23969324 | 0.76 | PLK1 (0.40) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22176523 | 0.76 | SIGMAR1 (0.37) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22175863 | 0.76 | SIGMAR1 (0.37) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22175858 | 0.75 | L3MBTL4 (0.38) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22176129 | 0.75 | L3MBTL4 (0.38) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL23969212 | 0.74 | SIGMAR1 (0.37) | L3MBTL4L3MBTL3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22176371 | 0.72 | SIGMAR1 (0.36) | HTTSMN1; SMN2 | |
| SCHEMBL23969437 | 0.68 | SIGMAR1 (0.33) | L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |