Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 11/20 | 0.54 |
| ▸ | PRKCH | P24723 | 1/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16941497 | 0.86 | HPGD (0.65) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL22201369 | 0.84 | LMNA (0.63) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL22201279 | 0.80 | ABCG2 (0.85) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL29007280 | 0.78 | ADORA3 (0.57) | HPGDLMNAALDH1A1POLBABCG2 | |
| SCHEMBL1083761 | 0.78 | HPGD (1.00) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL22201257 | 0.77 | FGFR2 (0.62) | HPGDLMNAPRKCHPRKCECYP1A2 | |
| SCHEMBL30390170 | 0.76 | ABCG2 (0.60) | HPGDLMNAALDH1A1ABCG2CYP1A2 | |
| SCHEMBL29007307 | 0.76 | ABCG2 (0.60) | HPGDLMNAALDH1A1ABCG2CYP1A2 | |
| SCHEMBL22201655 | 0.76 | PRKCH (0.48) | ALDH1A1PRKCHPRKCECYP1A2KDM4E | |
| SCHEMBL22201268 | 0.76 | TGFBR1 (0.51) | PRKCHPRKCEEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |