Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.33 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201489 | 0.89 | SYK (0.37) | TGFBR1SYKPRKD1P2RX3EGFR | |
| SCHEMBL22201531 | 0.85 | ABL1 (0.38) | TGFBR1SYKPRKD1ALOX12ALDH1A1 | |
| SCHEMBL22201281 | 0.84 | SYK (0.36) | TGFBR1SYKPRKD1ALOX12ALDH1A1 | |
| SCHEMBL22201368 | 0.82 | SYK (0.45) | TGFBR1SYKPRKD1ALOX12ALDH1A1 | |
| SCHEMBL22201225 | 0.82 | TGFBR1 (0.38) | TGFBR1SYKPRKD1ALOX12ALDH1A1 | |
| SCHEMBL22201421 | 0.81 | SYK (0.36) | TGFBR1SYKPRKD1P2RX3KCNH2 | |
| SCHEMBL22201494 | 0.81 | JAK2 (0.36) | TGFBR1SYKP2RX3PIP4K2CLMNA | |
| SCHEMBL22201273 | 0.81 | SYK (0.37) | TGFBR1SYKPRKD1ALDH1A1P2RX3 | |
| SCHEMBL22201226 | 0.81 | PRKCH (0.37) | TGFBR1SYKPRKD1P2RX3KCNH2 | |
| SCHEMBL22201586 | 0.81 | PRKCH (0.47) | TGFBR1SYKALDH1A1ROCK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |