Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.33 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201368 | 0.86 | SYK (0.45) | TGFBR1GRM4CYP1A2ADORA3SYK | |
| SCHEMBL22201536 | 0.86 | ACP1 (0.36) | TGFBR1GRM4CYP1A2ADORA3SYK | |
| SCHEMBL22201586 | 0.84 | PRKCH (0.47) | TGFBR1SYKALDH1A1 | |
| SCHEMBL22201489 | 0.84 | SYK (0.37) | TGFBR1GRM4CYP1A2ADORA3SYK | |
| SCHEMBL22201286 | 0.83 | P2RX3 (0.40) | TGFBR1ADORA3SYKALDH1A1ALOX12 | |
| SCHEMBL22201324 | 0.83 | ADORA3 (0.39) | TGFBR1GRM4CYP1A2ADORA3SYK | |
| SCHEMBL22201494 | 0.83 | JAK2 (0.36) | TGFBR1GRM4CYP1A2SYKP2RX3 | |
| SCHEMBL22201366 | 0.83 | MAPT (0.39) | CYP1A2SYKALDH1A1 | |
| SCHEMBL22201226 | 0.83 | PRKCH (0.37) | TGFBR1GRM4CYP1A2ADORA3SYK | |
| SCHEMBL22201223 | 0.83 | GRM4 (0.38) | TGFBR1GRM4CYP1A2ADORA3MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |