Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 1/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | BAD | Q92934 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 4/20 | 0.52 |
| ▸ | RXRB | P28702 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12160935 | 0.84 | TSHR (0.55) | SLC22A2SLC22A1SLC22A3SLC6A4TP53 | |
| SCHEMBL16000663 | 0.83 | QDPR (0.50) | SLC22A2SLC22A1SLC22A3SLC6A4LMNA | |
| Hydrochloric Acid SCHEMBL28336463 | 0.82 | TSHR (0.52) | SLC22A2SLC22A1SLC22A3SLC6A4TP53 | |
| Hydrochloric Acid SCHEMBL19877380 | 0.82 | TSHR (0.52) | SLC22A2SLC22A1SLC22A3SLC6A4TP53 | |
| SCHEMBL15423843 | 0.80 | RAB9A (0.60) | SLC22A2SLC22A1SLC22A3SLC6A4LMNA | |
| SCHEMBL22204594 | 0.79 | USP2 (0.50) | SLC22A2SLC22A1SLC22A3SLC6A4 | |
| SCHEMBL69873 | 0.79 | TSHR (0.80) | BCL2L1BADRXRARXRBTP53 | |
| SCHEMBL14018385 | 0.79 | TSHR (0.80) | BCL2L1BADRXRARXRBTP53 | |
| SCHEMBL2637326 | 0.79 | TSHR (0.80) | BCL2L1BADRXRARXRBTP53 | |
| Terephthalic Acid SCHEMBL9577834 | 0.79 | TSHR (0.80) | BCL2L1BADRXRARXRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11512084-B2 | Degradation agent using autophagic mechanism of damaged mitochondria | TOHOKU UNIVERSITY (JP) | 2022-11-29 | — | — | US | disclosed |
| US-20200223848-A1 | DEGRADATION AGENT USING AUTOPHAGIC MECHANISM OF DAMAGED MITOCHONDRIA | TOHOKU UNIVERSITY (JP) | 2020-07-16 | — | — | US | disclosed |
| EP-3679935-A1 | DEGRADATION AGENT USING AUTOPHAGIC MECHANISM OF DAMAGED MITOCHONDRIA | Tohoku University (JP) | 2020-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200223848-A1 | DEGRADATION AGENT USING AUTOPHAGIC MECHANISM OF DAMAGED MITOCHONDRIA | HSPA9, ATG7, TFAM | SLC22A2 1997/4885SLC22A1 1696/4885SLC22A3 2243/4885 |
| US-11512084-B2 | Degradation agent using autophagic mechanism of damaged mitochondria | HSPA9, ATG7, TFAM | SLC22A2 1997/4885SLC22A1 1696/4885SLC22A3 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.