Sugi Predict

Sugi Predict / Compounds / SCHEMBL2220583

SCHEMBL2220583

SCHEMBL2220583

CCOc1ccc(O)cc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 1/20 0.54
▸ MAPT P10636 5/20 0.50
▸ RAB9A P51151 3/20 0.50
▸ L3MBTL1 Q9Y468 2/20 0.50
▸ ATM Q13315 1/20 0.50
▸ ERN1 O75460 1/20 0.47
▸ LMNA P02545 3/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ HSD17B10 Q99714 1/20 0.46
▸ POLB P06746 3/20 0.46
▸ GAA P10253 3/20 0.46
▸ KMT2A Q03164 3/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ MCL1 Q07820 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ CALM1 P0DP23 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ TSHR P16473 1/20 0.44
▸ TP53 P04637 2/20 0.43
▸ NPC1 O15118 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3724251 0.85 CSNK2A1 (0.60) MAPTRAB9AL3MBTL1ATMSMN1; SMN2
SCHEMBL3172287 0.84 HSD17B10 (0.46) RORCMAPTRAB9ALMNASMN1; SMN2
SCHEMBL10709145 0.83 HSD17B10 (0.50) MAPTRAB9AL3MBTL1HSD17B10POLB
SCHEMBL19646170 0.81 ALDH1A1 (0.44) RORCMAPTRAB9AL3MBTL1ATM
SCHEMBL3026188 0.81 CALM1 (0.51) MAPTLMNAHSD17B10POLBGAA
SCHEMBL3721034 0.81 HSD17B10 (0.43) MAPTHSD17B10TDP1TSHRCYP1A2
SCHEMBL9698942 0.80 THRA (0.54) RAB9AL3MBTL1ATMSMN1; SMN2KMT2A
SCHEMBL9734720 0.80 THRA (0.54) RAB9AL3MBTL1ATMSMN1; SMN2KMT2A
SCHEMBL9698883 0.80 THRA (0.54) RAB9AL3MBTL1ATMSMN1; SMN2KMT2A
SCHEMBL9647635 0.80 THRA (0.54) RAB9AL3MBTL1ATMSMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5151458-A Molding materials for liquid crystal resins BAYER AKTIENGESELLSCHAFT (DE) 1992-09-29 — — US claimed
US-5143956-A Blends with low molecular weight liquid crystals BAYER AKTIENGESELLSCHAFT (DE) 1992-09-01 — — US claimed
CN-122036680-A Anti-fibrotic pyridones 英特穆恩公司 2026-05-15 — — CN disclosed
CN-114950548-A Application of eutectic ionic liquid in preparation of phenol or derivatives thereof by dealkylation of phenol alkyl ether compounds 宁夏中星显示材料有限公司 2022-08-30 — — CN disclosed
CN-110452216-B Anti-fibrotic pyridinones 英特穆恩公司 2022-08-26 — — CN disclosed
US-10898474-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2021-01-26 — — US disclosed
EP-2903991-B1 ANTI-FIBROTIC PYRIDINONES INTERMUNE INC (US) 2020-09-16 — — EP disclosed
US-10544161-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2020-01-28 — — US disclosed
US-20190321343-A1 Anti-Fibrotic Pyridinones GENENTECH, INC. 2019-10-24 — — US disclosed
US-10376497-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2019-08-13 — — US disclosed
US-20190144467-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2019-05-16 — — US disclosed
US-5030703-A Polyesters, polycarbonateesters, polylactones BAYER AKTIENGESELLSCHAFT (DE) 1991-07-09 — — US disclosed
EP-0406745-A1 Antibiotic GE 2270 factors A1, A2, A3 and H GRUPPO LEPETIT S.p.A. (IT) 1991-01-09 — — EP disclosed
US-4960539-A Use of fluoromethylphenols as solvents for LC-polymers, and new fluoromethylphenols BAYER AKTIENGESELLSCHAFT (DE) 1990-10-02 — — US disclosed
US-4945130-A Molding compositions of polycarbonate, thermotropic polymer, graft polymer and fluorinated polyolefin BAYER AKTIENGESELLSCHAFT (DE) 1990-07-31 — — US disclosed
US-4886869-A OPTIONALLY SUBSTITUTED WITH-3-HYDROXY BENZOIC ACID; RIGIDITY, IMPACT STRENGTH AND ELONGATION BAYER AKTIENGESELLSCHAFT (DE) 1989-12-12 — — US disclosed
US-4599395-A Thermotropic, aromatic polyesters having good mechanical strength, containing sulfonic acid groups or metal sulfonate groups a process for the production thereof BAYER AKTIENGESELLSCHAFT (DE) 1986-07-08 — — US disclosed
EP-0024499-B1 BIAXIALLY ORIENTED WHOLLY AROMATIC POLYESTER FILM AND PROCESS FOR PRODUCING SAME TEIJIN LIMITED (JP) 1984-03-07 — — EP disclosed
US-4333907-A Biaxially oriented wholly aromatic polyester film TEITIN LIMITED (JP) 1982-06-08 — — US disclosed
EP-0024499-A1 Biaxially oriented wholly aromatic polyester film and process for producing same TEIJIN LIMITED (JP) 1981-03-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10544161-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 RORC 1349/4885MAPT 4377/4885RAB9A 2353/4885
US-20190321343-A1 Anti-Fibrotic Pyridinones MMP1, COL1A1, COL2A1 RORC 1349/4885MAPT 4377/4885RAB9A 2353/4885
US-10376497-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 RORC 1349/4885MAPT 4377/4885RAB9A 2353/4885
US-10898474-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 RORC 1349/4885MAPT 4377/4885RAB9A 2353/4885
US-20190144467-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 RORC 1349/4885MAPT 4377/4885RAB9A 2353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.