Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.82 |
| ▸ | HPGD | P15428 | 7/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 5/20 | 0.75 |
| ▸ | GAA | P10253 | 3/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.75 |
| ▸ | GLA | P06280 | 2/20 | 0.75 |
| ▸ | SQOR | Q9Y6N5 | 10/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 2/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22215730 | 0.90 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL22215651 | 0.89 | KDM4E (0.80) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL29442266 | 0.89 | ALDH1A1 (0.80) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL6253649 | 0.88 | ADORA2A (0.74) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL22215727 | 0.87 | ALDH1A1 (0.77) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL22215728 | 0.86 | KDM4E (1.00) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL29442368 | 0.82 | KDM4E (0.70) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL3590231 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL3597920 | 0.80 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL13514245 | 0.80 | KDM4E (0.66) | ALDH1A1HPGDKDM4ENPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | claimed |
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | disclosed |
| WO-2020146636-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE | DREXEL UNIVERSITY (US) | 2020-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | SQOR, QSOX1, KEAP1 | ALDH1A1 411/4885HPGD 62/4885KDM4E 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.