Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12868961 | 0.83 | LTA4H (0.49) | PPARGMAPTL3MBTL1TEAD1PTGER4 | |
| SCHEMBL24726470 | 0.82 | PPARG (0.43) | PPARGMAPTNPSR1L3MBTL1TEAD1 | |
| SCHEMBL25917913 | 0.82 | STK39 (0.50) | STK39EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL14020503 | 0.81 | PPARG (0.51) | HTR2APPARGMAPTL3MBTL1TEAD1 | |
| SCHEMBL15832050 | 0.81 | L3MBTL1 (0.60) | STK39EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL10538095 | 0.79 | NPSR1 (0.57) | STK39EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL2736379 | 0.79 | FFAR1 (0.49) | STK39MRGPRX4FFAR1 | |
| SCHEMBL10482077 | 0.79 | MRGPRX4 (0.53) | STK39EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL11121304 | 0.79 | STK39 (0.50) | STK39EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL29638122 | 0.79 | EGFR (0.53) | STK39EGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124483-B2 | HER3 ligands and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200223799-A1 | HER3 LIGANDS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124483-B2 | HER3 ligands and uses thereof | ERBB3, ERBB2, EGFR | STK39 3442/4885EGFR 3/4885ERBB2 2/4885 |
| US-20200223799-A1 | HER3 LIGANDS AND USES THEREOF | ERBB3, ERBB2, EGFR | STK39 3442/4885EGFR 3/4885ERBB2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.